Fishing for neuroendocrine tumors

Research output: Contribution to journalReview articlepeer-review

Abstract

Neuroendocrine tumors (NETs) are a class of rare and heterogeneous neoplasms that originate from the neuroendocrine system. In several cases, these neoplasms can release bioactive hormones leading to characteristic clinical syndromes and hormonal dysregulations with detrimental impact on the quality of life and survival of these patients. Only few animal models are currently available to investigate pathogenesis, progression and functional syndromes in NETs and to identify new therapeutic strategies. The tropical teleost zebrafish (Danio rerio) is a popular vertebrate model system that offers unique advantages for the study of several biological processes, ranging from embryonic development to human diseases such as cancer. In this review, we summarize recent advances on zebrafish models for NET preclinical research that take advantage of modern genetic and transplantable technologies. In the future, these tools may have a role in the treatment decision-making and tertiary prevention of NETs.

Original languageEnglish
Pages (from-to)R163-R176
JournalEndocrine-Related Cancer
Volume27
Issue number6
DOIs
Publication statusPublished - 2020

Keywords

  • Neuroendocrine tumors
  • Patient-derived xenograft
  • Tumor xenograft
  • Zebrafish

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Cancer Research

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