Fishing in the Cell Powerhouse: Zebrafish as A Tool for Exploration of Mitochondrial Defects Affecting the Nervous System

Gianluca Fichi, Valentina Naef, Amilcare Barca, Giovanna Longo, Baldassare Fronte, Tiziano Verri, Filippo M. Santorelli, Maria Marchese, Vittoria Petruzzella

Research output: Contribution to journalReview article

Abstract

The zebrafish (Danio rerio) is a small vertebrate ideally suited to the modeling of human diseases. Large numbers of genetic alterations have now been modeled and could be used to study organ development by means of a genetic approach. To date, limited attention has been paid to the possible use of the zebrafish toolbox in studying human mitochondrial disorders affecting the nervous system. Here, we review the pertinent scientific literature discussing the use of zebrafish in modeling gene mutations involved in mitochondria-related neurological human diseases. A critical analysis of the literature suggests that the zebrafish not only lends itself to exploration of the pathological consequences of mitochondrial energy output on the nervous system but could also serve as an attractive platform for future drugs in an as yet untreatable category of human disorders.

Original languageEnglish
JournalInternational Journal of Molecular Sciences
Volume20
Issue number10
DOIs
Publication statusPublished - May 15 2019

Keywords

  • mitochondria
  • nervous system development
  • neurodegenerative conditions
  • zebrafish

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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  • Cite this

    Fichi, G., Naef, V., Barca, A., Longo, G., Fronte, B., Verri, T., Santorelli, F. M., Marchese, M., & Petruzzella, V. (2019). Fishing in the Cell Powerhouse: Zebrafish as A Tool for Exploration of Mitochondrial Defects Affecting the Nervous System. International Journal of Molecular Sciences, 20(10). https://doi.org/10.3390/ijms20102409