Five day intermittent vs seven day continuous 2-chlorodeoxyadenosine infusion for the treatment of hairy cell leukemia. A study by Italian group for the hairy cell leukemia

E. E. Damasio, L. Resegotti, B. Masoudi, R. Bruni, R. Cerri, A. Isaza, M. Clavio, M. Risso, E. Rossi, M. Spriano, M. Truini

Research output: Contribution to journalArticlepeer-review

Abstract

The new purine-analogue 2-chlorodeoxyadenosine (2-CdA) has proved to induce an high CR rate and a long lasting disease free survival. In this study we compare the efficacy and toxicity of 2-CdA employed in two different schedules (A and B). Forty-one patients have been enrolled from 1994: 22 p. (group A) were treated with a single cycle of 2-CdA given as two hour i.v. infusion on 5 consecutive days (0.15 mg/kg/die); while 19 p. (group B) with continuous i.v. infusion for 7 consecutive days (0.10 mg/kg/die). Response criteria were those proposed by NCI. The Hairy Cell Index (HCI) was calculated using DBA44 MoAb. At three months, the responses in group A (19/22) were: 5 CR (26.3%), 6 GPR (31.5%), 5 PR and 3 NR.; in group B (17/19): 6 CR (35.3%), 3 GPR (17.6%), 4 PR and 4 NR. Overall response at six months was respectively 84.2% and 76.5%. At six months the responses were: in group A (18/22): 9 CR (50%), 4 GPR (22.2%), 3 PR, 2 NR; in group B (16/19): 4 CR (25%), 6 GPR (37.5%), 3 PR, 3 NR. Overall response at 6 months was respectively 88.8% (group A) and 81.2% (group B). The 5 day intermittent schedule appears efficient, well tolerated and suitable for out-patient treatment. DBA44 MoAb appears useful to better define the HCI and to distinguish CR from GPR.

Original languageEnglish
Pages (from-to)68-74
Number of pages7
JournalRecenti Progressi in Medicina
Volume89
Issue number2
Publication statusPublished - 1998

Keywords

  • 2-chlorodeoxyadenosine
  • DBA44 monoclonal antibody
  • Hairy cell leukemia
  • HCI

ASJC Scopus subject areas

  • Medicine(all)

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