Five human immunodeficiency virus type 1 phenotypic variants with different MT-2 cell tropisms correlate with prognostic markers of disease

Emanuele Nicastri, Lucia Ercoli, Loredana Sarmati, Laura Ventura, Saverio Giuseppe Parisi, Cinthia Ciapetti, Marco Montano, Massimo Andreoni

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: We correlated virologic and immunologic parameters of disease progression with cytopathogenicity of HIV isolates. Study Design/Methods: Human immunodeficiency virus type 1 (HIV-1) isolates from 207 patients with CD4+ cell counts 3 were examined for biologic phenotype in MT-2 cells. We used a cross-sectional study design. Results: Three subtypes of syncytium-inducing (SI) strains with different times of appearance of syncytia formation in cell culture and two subtypes of non-syncytium-inducing (NSI) isolates, with (NSI/MT2+) or without (NSI/MT2-) replicative capacity in MT-2 cells, were identified. Early SI strains were associated with the lowest CD4+ cell counts and the highest levels of viral load, and NSI/MT2- isolates correlated with the highest CD+ cell counts and the lowest viral loads. Patients with late SI and NSI/MT2+ strains showed minimal differences in immunologic and virologic markers. Conclusions: Five HIV phenotypic variants that correlate significantly (P <0.001) with markers of disease progression were identified.

Original languageEnglish
Pages (from-to)90-95
Number of pages6
JournalJournal of Human Virology
Volume1
Issue number2
Publication statusPublished - Jan 1998

Keywords

  • Biologic phenotype
  • CD4 counts
  • Disease progression
  • Human immunodeficiency virus strains
  • Viral load

ASJC Scopus subject areas

  • Virology

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