Five-year PFS from the AETHERA trial of brentuximab vedotin for Hodgkin lymphoma at high risk of progression or relapse

Craig H Moskowitz, Jan Walewski, Auayporn Nademanee, Tamas Masszi, Edward Agura, Jerzy Holowiecki, Muneer H Abidi, Andy I Chen, Patrick Stiff, Simonetta Viviani, Veronika Bachanova, Anna Sureda, Teresa McClendon, Connie Lee, Julie Lisano, John Sweetenham

Research output: Contribution to journalArticle

Abstract

The phase 3 AETHERA trial established brentuximab vedotin (BV) as a consolidative treatment option for adult patients with classical Hodgkin lymphoma (cHL) at high risk of relapse or progression after autologous hematopoietic stem-cell transplantation (auto-HSCT). Results showed that BV significantly improved progression-free survival (PFS) vs placebo plus best supportive care alone. At 5-year follow-up, BV continued to provide patients with sustained PFS benefit; 5-year PFS was 59% (95% confidence interval [CI], 51-66) with BV vs 41% (95% CI, 33-49) with placebo (hazard ratio [HR], 0.521; 95% CI, 0.379-0.717). Similarly, patients with ≥2 risk factors in the BV arm experienced significantly higher PFS at 5 years than patients in the placebo arm (HR, 0.424; 95% CI, 0.302-0.596). Upfront consolidation with BV significantly delayed time to second subsequent therapy, an indicator of ongoing disease control, vs placebo. Peripheral neuropathy, the most common adverse event in patients receiving BV, continued to improve and/or resolve in 90% of patients. In summary, consolidation with BV in adult patients with cHL at high risk of relapse or progression after auto-HSCT confers a sustained PFS benefit and is safe and well tolerated. Physicians should consider each patient's HL risk factor profile when making treatment decisions. This trial was registered at www.clinicaltrials.gov as #NCT01100502.

Original languageEnglish
Pages (from-to)2639-2642
Number of pages4
JournalBlood
Volume132
Issue number25
DOIs
Publication statusPublished - Dec 20 2018

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Hodgkin Disease
Disease-Free Survival
Recurrence
Placebos
Confidence Intervals
Hematopoietic Stem Cell Transplantation
cAC10-vcMMAE
Peripheral Nervous System Diseases
Decision Making
Therapeutics
Physicians

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Moskowitz, C. H., Walewski, J., Nademanee, A., Masszi, T., Agura, E., Holowiecki, J., ... Sweetenham, J. (2018). Five-year PFS from the AETHERA trial of brentuximab vedotin for Hodgkin lymphoma at high risk of progression or relapse. Blood, 132(25), 2639-2642. https://doi.org/10.1182/blood-2018-07-861641

Five-year PFS from the AETHERA trial of brentuximab vedotin for Hodgkin lymphoma at high risk of progression or relapse. / Moskowitz, Craig H; Walewski, Jan; Nademanee, Auayporn; Masszi, Tamas; Agura, Edward; Holowiecki, Jerzy; Abidi, Muneer H; Chen, Andy I; Stiff, Patrick; Viviani, Simonetta; Bachanova, Veronika; Sureda, Anna; McClendon, Teresa; Lee, Connie; Lisano, Julie; Sweetenham, John.

In: Blood, Vol. 132, No. 25, 20.12.2018, p. 2639-2642.

Research output: Contribution to journalArticle

Moskowitz, CH, Walewski, J, Nademanee, A, Masszi, T, Agura, E, Holowiecki, J, Abidi, MH, Chen, AI, Stiff, P, Viviani, S, Bachanova, V, Sureda, A, McClendon, T, Lee, C, Lisano, J & Sweetenham, J 2018, 'Five-year PFS from the AETHERA trial of brentuximab vedotin for Hodgkin lymphoma at high risk of progression or relapse', Blood, vol. 132, no. 25, pp. 2639-2642. https://doi.org/10.1182/blood-2018-07-861641
Moskowitz CH, Walewski J, Nademanee A, Masszi T, Agura E, Holowiecki J et al. Five-year PFS from the AETHERA trial of brentuximab vedotin for Hodgkin lymphoma at high risk of progression or relapse. Blood. 2018 Dec 20;132(25):2639-2642. https://doi.org/10.1182/blood-2018-07-861641
Moskowitz, Craig H ; Walewski, Jan ; Nademanee, Auayporn ; Masszi, Tamas ; Agura, Edward ; Holowiecki, Jerzy ; Abidi, Muneer H ; Chen, Andy I ; Stiff, Patrick ; Viviani, Simonetta ; Bachanova, Veronika ; Sureda, Anna ; McClendon, Teresa ; Lee, Connie ; Lisano, Julie ; Sweetenham, John. / Five-year PFS from the AETHERA trial of brentuximab vedotin for Hodgkin lymphoma at high risk of progression or relapse. In: Blood. 2018 ; Vol. 132, No. 25. pp. 2639-2642.
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abstract = "The phase 3 AETHERA trial established brentuximab vedotin (BV) as a consolidative treatment option for adult patients with classical Hodgkin lymphoma (cHL) at high risk of relapse or progression after autologous hematopoietic stem-cell transplantation (auto-HSCT). Results showed that BV significantly improved progression-free survival (PFS) vs placebo plus best supportive care alone. At 5-year follow-up, BV continued to provide patients with sustained PFS benefit; 5-year PFS was 59{\%} (95{\%} confidence interval [CI], 51-66) with BV vs 41{\%} (95{\%} CI, 33-49) with placebo (hazard ratio [HR], 0.521; 95{\%} CI, 0.379-0.717). Similarly, patients with ≥2 risk factors in the BV arm experienced significantly higher PFS at 5 years than patients in the placebo arm (HR, 0.424; 95{\%} CI, 0.302-0.596). Upfront consolidation with BV significantly delayed time to second subsequent therapy, an indicator of ongoing disease control, vs placebo. Peripheral neuropathy, the most common adverse event in patients receiving BV, continued to improve and/or resolve in 90{\%} of patients. In summary, consolidation with BV in adult patients with cHL at high risk of relapse or progression after auto-HSCT confers a sustained PFS benefit and is safe and well tolerated. Physicians should consider each patient's HL risk factor profile when making treatment decisions. This trial was registered at www.clinicaltrials.gov as #NCT01100502.",
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AU - Moskowitz, Craig H

AU - Walewski, Jan

AU - Nademanee, Auayporn

AU - Masszi, Tamas

AU - Agura, Edward

AU - Holowiecki, Jerzy

AU - Abidi, Muneer H

AU - Chen, Andy I

AU - Stiff, Patrick

AU - Viviani, Simonetta

AU - Bachanova, Veronika

AU - Sureda, Anna

AU - McClendon, Teresa

AU - Lee, Connie

AU - Lisano, Julie

AU - Sweetenham, John

N1 - © 2018 by The American Society of Hematology.

PY - 2018/12/20

Y1 - 2018/12/20

N2 - The phase 3 AETHERA trial established brentuximab vedotin (BV) as a consolidative treatment option for adult patients with classical Hodgkin lymphoma (cHL) at high risk of relapse or progression after autologous hematopoietic stem-cell transplantation (auto-HSCT). Results showed that BV significantly improved progression-free survival (PFS) vs placebo plus best supportive care alone. At 5-year follow-up, BV continued to provide patients with sustained PFS benefit; 5-year PFS was 59% (95% confidence interval [CI], 51-66) with BV vs 41% (95% CI, 33-49) with placebo (hazard ratio [HR], 0.521; 95% CI, 0.379-0.717). Similarly, patients with ≥2 risk factors in the BV arm experienced significantly higher PFS at 5 years than patients in the placebo arm (HR, 0.424; 95% CI, 0.302-0.596). Upfront consolidation with BV significantly delayed time to second subsequent therapy, an indicator of ongoing disease control, vs placebo. Peripheral neuropathy, the most common adverse event in patients receiving BV, continued to improve and/or resolve in 90% of patients. In summary, consolidation with BV in adult patients with cHL at high risk of relapse or progression after auto-HSCT confers a sustained PFS benefit and is safe and well tolerated. Physicians should consider each patient's HL risk factor profile when making treatment decisions. This trial was registered at www.clinicaltrials.gov as #NCT01100502.

AB - The phase 3 AETHERA trial established brentuximab vedotin (BV) as a consolidative treatment option for adult patients with classical Hodgkin lymphoma (cHL) at high risk of relapse or progression after autologous hematopoietic stem-cell transplantation (auto-HSCT). Results showed that BV significantly improved progression-free survival (PFS) vs placebo plus best supportive care alone. At 5-year follow-up, BV continued to provide patients with sustained PFS benefit; 5-year PFS was 59% (95% confidence interval [CI], 51-66) with BV vs 41% (95% CI, 33-49) with placebo (hazard ratio [HR], 0.521; 95% CI, 0.379-0.717). Similarly, patients with ≥2 risk factors in the BV arm experienced significantly higher PFS at 5 years than patients in the placebo arm (HR, 0.424; 95% CI, 0.302-0.596). Upfront consolidation with BV significantly delayed time to second subsequent therapy, an indicator of ongoing disease control, vs placebo. Peripheral neuropathy, the most common adverse event in patients receiving BV, continued to improve and/or resolve in 90% of patients. In summary, consolidation with BV in adult patients with cHL at high risk of relapse or progression after auto-HSCT confers a sustained PFS benefit and is safe and well tolerated. Physicians should consider each patient's HL risk factor profile when making treatment decisions. This trial was registered at www.clinicaltrials.gov as #NCT01100502.

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