Abstract
Original language | English |
---|---|
Pages (from-to) | 1759-1770 |
Number of pages | 12 |
Journal | Thyroid |
Volume | 30 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- 5 years
- benign thyroid nodules
- cumulative incidence
- follow-up
- laser
- regrowth
- retreatment
- RFA
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Five-Year Results of Radiofrequency and Laser Ablation of Benign Thyroid Nodules: A Multicenter Study from the Italian Minimally Invasive Treatments of the Thyroid Group. / Bernardi, S.; Giudici, F.; Cesareo, R.; Antonelli, G.; Cavallaro, M.; Deandrea, M.; Giusti, M.; Mormile, A.; Negro, R.; Palermo, A.; Papini, E.; Pasqualini, V.; Raggiunti, B.; Rossi, D.; Sconfienza, L.M.; Solbiati, L.; Spiezia, S.; Tina, D.; Vera, L.; Stacul, F.; Mauri, G.
In: Thyroid, Vol. 30, No. 12, 2020, p. 1759-1770.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Five-Year Results of Radiofrequency and Laser Ablation of Benign Thyroid Nodules: A Multicenter Study from the Italian Minimally Invasive Treatments of the Thyroid Group
AU - Bernardi, S.
AU - Giudici, F.
AU - Cesareo, R.
AU - Antonelli, G.
AU - Cavallaro, M.
AU - Deandrea, M.
AU - Giusti, M.
AU - Mormile, A.
AU - Negro, R.
AU - Palermo, A.
AU - Papini, E.
AU - Pasqualini, V.
AU - Raggiunti, B.
AU - Rossi, D.
AU - Sconfienza, L.M.
AU - Solbiati, L.
AU - Spiezia, S.
AU - Tina, D.
AU - Vera, L.
AU - Stacul, F.
AU - Mauri, G.
N1 - Cited By :9 Export Date: 1 March 2021 CODEN: THYRE Correspondence Address: Bernardi, S.; Dipartimento di Scienze Mediche, Italy; email: stella.bernardi@asuits.sanita.fvg.it References: Papini, E, Gugliemi, R, Pacella, CM, Laser, radiofrequency, and ethanol ablation for the management of thyroid nodules (2016) Curr Opin Endocrinol Diabetes Obes, 23, pp. 400-406; Gharib, H, Papini, E, Garber, JR, Duick, DS, Harrell, RM, Hegedus, L, Paschke, R, Vitti, P, American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules-2016 Update (2016) Endocr Pract, 22, pp. 622-639; Kim, JH, Baek, JH, Lim, HK, Ahn, HS, Baek, SM, Choi, YJ, Choi, YJ, Na, DG, Guideline Committee for the Korean Society of Thyroid Radiology, Korean Society of Radiology 2018 2017 Thyroid Radiofrequency Ablation Guideline: Korean Society of Thyroid Radiology Korean J Radiol, 19, pp. 632-655; Papini, E, Pacella, CM, Solbiati, LA, Achille, G, Barbaro, D, Bernardi, S, Cantisani, V, Mauri, G, Minimally-invasive treatments for benign thyroid nodules: a Delphi-based consensus statement from the Italian minimally-invasive treatments of the thyroid (MITT) group (2019) Int J Hyperthermia, 36, pp. 376-382; Gharib, H, Hegedus, L, Pacella, CM, Baek, JH, Papini, E, Clinical review: nonsurgical, image-guided, minimally invasive therapy for thyroid nodules (2013) J Clin Endocrinol Metab, 98, pp. 3949-3957; Cesareo, R, Pasqualini, V, Simeoni, C, Sacchi, M, Saralli, E, Campagna, G, Cianni, R, Prospective study of effectiveness of ultrasound-guided radiofrequency ablation versus control group in patients affected by benign thyroid nodules (2015) J Clin Endocrinol Metab, 100, pp. 460-466; Deandrea, M, Sung, JY, Limone, P, Mormile, A, Garino, F, Ragazzoni, F, Kim, KS, Baek, JH, Efficacy and safety of radiofrequency ablation versus observation for nonfunctioning benign thyroid nodules: a randomized controlled international collaborative trial (2015) Thyroid, 25, pp. 890-896; Papini, E, Rago, T, Gambelunghe, G, Valcavi, R, Bizzarri, G, Vitti, P, De Feo, P, Pacella, CM, Long-term efficacy of ultrasound-guided laser ablation for benign solid thyroid nodules. Results of a threeyear multicenter prospective randomized trial (2014) J Clin Endocrinol Metab, 99, pp. 3653-3659; Kim, C, Lee, JH, Choi, YJ, Kim, WB, Sung, TY, Baek, JH, Complications encountered in ultrasonographyguided radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers (2017) Eur Radiol, 27, pp. 3128-3137; Pacella, CM, Mauri, G, Achille, G, Barbaro, D, Bizzarri, G, De Feo, P, Di Stasio, E, Papini, E, Outcomes and risk factors for complications of laser ablation for thyroid nodules: a multicenter study on 1531 patients (2015) J Clin Endocrinol Metab, 100, pp. 3903-3910; Nardi, F, Basolo, F, Crescenzi, A, Fadda, G, Frasoldati, A, Orlandi, F, Palombini, L, Vitti, P, Italian consensus for the classification and reporting of thyroid cytology (2014) J Endocrinol Investig, 37, pp. 593-599; Cibas, ES, Ali, SZ, The Bethesda System For Reporting Thyroid Cytopathology (2009) Am J Clin Pathol, 132, pp. 658-665. , Conference NCITFSotS; Mauri, G, Pacella, CM, Papini, E, Sconfienza, LM, Solbiati, L, Proceedings of the first Italian conference on thyroid minimally invasive treatments and foundation of the Italian research group for thyroid minimally invasive procedures (2018) Int J Hyperthermia, 34, pp. 603-605; Trimboli, P, Deandrea, M, Treating thyroid nodules by radiofrequency: is the delivered energy correlated with the volume reduction rate? A pilot study (2020) Endocrine, , [Epub ahead of print]; Cooper, DS, Doherty, GM, Haugen, BR, Kloos, RT, Lee, SL, Mandel, SJ, Mazzaferri, EL, Tuttle, RM, Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer (2009) Thyroid, 19, pp. 1167-1214. , American Thyroid Association Guidelines Taskforce on Thyroid Nodules, Differentiated Thyroid Cancer; Mauri, G, Pacella, CM, Papini, E, Solbiati, L, Goldberg, SN, Ahmed, M, Sconfienza, LM, Image-guided thyroid ablation: proposal for standardization of terminology and reporting criteria (2019) Thyroid, 29, pp. 611-618; Ahmed, M, Solbiati, L, Brace, CL, Breen, DJ, Callstrom, MR, Charboneau, JW, Chen, MH, Goldberg, SN, International Working Group on Image-guided Tumor Ablation, Interventional Oncology Sans Frontieres Expert Panel, Technology Assessment Committee of the Society of Interventional Radiology, Standard of Practice Committee of the Cardiovascular, Interventional Radiological Society of Europe 2014 Image-guided tumor ablation: standardization of terminology and reporting criteria-a 10-year update Radiology, 273, pp. 241-260; Sim, JS, Baek, JH, Lee, J, Cho, W, Jung, SI, Radiofrequency ablation of benign thyroid nodules: depicting early sign of regrowth by calculating vital volume (2017) Int J Hypertherm, 33, pp. 905-910; Kim, HT, Cumulative incidence in competing risks data and competing risks regression analysis (2007) Clin Cancer Res, 13, pp. 559-565; Scrucca, L, Santucci, A, Aversa, F, Competing risk analysis using R: an easy guide for clinicians (2007) Bone Marrow Transplant, 40, pp. 381-387; Pacella, CM, Bizzarri, G, Guglielmi, R, Anelli, V, Bianchini, A, Crescenzi, A, Pacella, S, Papini, E, Thyroid tissue: US-guided percutaneous interstitial laser ablation-a feasibility study (2000) Radiology, 217, pp. 673-677; Kim, YS, Rhim, H, Tae, K, Park, DW, Kim, ST, Radiofrequency ablation of benign cold thyroid nodules: initial clinical experience (2006) Thyroid, 16, pp. 361-367; Pacella, CM, Bizzarri, G, Spiezia, S, Bianchini, A, Guglielmi, R, Crescenzi, A, Pacella, S, Papini, E, Thyroid tissue: US-guided percutaneous laser thermal ablation (2004) Radiology, 232, pp. 272-280; Baek, JH, Lee, JH, Valcavi, R, Pacella, CM, Rhim, H, Na, DG, Thermal ablation for benign thyroid nodules: radiofrequency and laser (2011) Korean J Radiol, 12, pp. 525-540; Dossing, H, Bennedbaek, FN, Hegedus, L, Long-term outcome following interstitial laser photocoagulation of benign cold thyroid nodules (2011) Eur J Endocrinol, 165, pp. 123-128; Lim, HK, Lee, JH, Ha, EJ, Sung, JY, Kim, JK, Baek, JH, Radiofrequency ablation of benign non-functioning thyroid nodules: 4-year follow-up results for 111 patients (2013) Eur Radiol, 23, pp. 1044-1049; Deandrea, M, Trimboli, P, Garino, F, Mormile, A, Magliona, G, Ramunni, MJ, Giovanella, L, Limone, PP, Long-term efficacy of a single session of RFA for benign thyroid nodules: a longitudinal 5-year observational study (2019) J Clin Endocrinol Metabol, 104, pp. 3751-3756; Trimboli, P, Castellana, M, Sconfienza, LM, Virili, C, Pescatori, LC, Cesareo, R, Giorgino, F, Mauri, G, Efficacy of thermal ablation in benign nonfunctioning solid thyroid nodule: a systematic review and meta-analysis (2020) Endocrine, 67, pp. 35-43; Gambelunghe, G, Fede, R, Bini, V, Monacelli, M, Avenia, N, D'Ajello, M, Colella, R, De Feo, P, Ultrasoundguided interstitial laser ablation for thyroid nodules is effective only at high total amounts of energy: results from a three-year pilot study (2013) Surg Innov, 20, pp. 345-350; de Freitas, RMC, Miazaki, AP, Tsunemi, MH, de Araujo Filho, VJF, Marui, S, Danilovic, DLS, Buchpiguel, CA, Chammas, MC, Laser ablation of benign thyroid nodules: a prospective pilot study with a preliminary analysis of the employed energy (2020) Lasers Surg Med, 52, pp. 323-332; Pacella, CM, Mauri, G, Cesareo, R, Paqualini, V, Cianni, R, De Feo, P, Gambelunghe, G, Papini, E, A comparison of laser with radiofrequency ablation for the treatment of benign thyroid nodules: a propensity score matching analysis (2017) Int J Hyperthermia, 33, pp. 911-919; Ritz, JP, Lehmann, KS, Zurbuchen, U, Knappe, V, Schumann, T, Buhr, HJ, Holmer, C, Ex vivo and in vivo evaluation of laser-induced thermotherapy for nodular thyroid disease (2009) Lasers Surg Med, 41, pp. 479-486; Goldberg, SN, Gazelle, GS, Dawson, SL, Rittman, WJ, Mueller, PR, Rosenthal, DI, Tissue ablation with radiofrequency: effect of probe size, gauge, duration, and temperature on lesion volume (1995) Acad Radiol, 2, pp. 399-404; Ha, EJ, Baek, JH, Kim, KW, Pyo, J, Lee, JH, Baek, SH, Dossing, H, Hegedus, L, Comparative efficacy of radiofrequency and laser ablation for the treatment of benign thyroid nodules: systematic review including traditional pooling and bayesian network meta-analysis (2015) J Clin Endocrinol Metab, 100, pp. 1903-1911; Mauri, G, Cova, L, Monaco, CG, Sconfienza, LM, Corbetta, S, Benedini, S, Ambrogi, F, Solbiati, L, Benign thyroid nodules treatment using percutaneous laser ablation (PLA) and radiofrequency ablation (RFA) (2017) Int J Hyperthermia, 33, pp. 295-299; Cesareo, R, Pacella, CM, Pasqualini, V, Campagna, G, Iozzino, M, Gallo, A, Lauria Pantano, A, Palermo, A, Laser ablation versus radiofrequency ablation for benign non-functioning thyroid nodules: six-month results of a randomised, parallel, open-label, trial (LARA trial) (2020) Thyroid, 30, pp. 847-856; Valcavi, R, Riganti, F, Bertani, A, Formisano, D, Pacella, CM, Percutaneous laser ablation of cold benign thyroid nodules: a 3-year follow-up study in 122 patients (2010) Thyroid, 20, pp. 1253-1261; Sim, JS, Baek, JH, Long-term outcomes following thermal ablation of benign thyroid nodules as an alternative to surgery: the importance of controlling regrowth (2019) Endocrinol Metab (Seoul), 34, pp. 117-123; Negro, R, Greco, G, Unfavorable outcomes in solid and spongiform thyroid nodules treated with laser ablation. A 5- year follow-up retrospective study (2019) Endocr Metab Immune Disord Drug Targets, 19, pp. 1041-1045; Sim, JS, Baek, JH, Cho, W, Initial ablation ratio: quantitative value predicting the therapeutic success of thyroid radiofrequency ablation (2018) Thyroid, 28, pp. 1443-1449; Bernardi, S, Dobrinja, C, Fabris, B, Bazzocchi, G, Sabato, N, Ulcigrai, V, Giacca, M, Stacul, F, Radiofrequency ablation compared to surgery for the treatment of benign thyroid nodules (2014) Int J Endocrinol, 2014, p. 934595
PY - 2020
Y1 - 2020
N2 - Background: Radiofrequency ablation (RFA) and laser ablation (LA) are effective treatments for benign thyroid nodules. Due to their relatively recent introduction into clinical practice, there are limited long-term follow-up studies. This study aimed to evaluate technique efficacy, rate of regrowth, and retreatment over 5 years after RFA or LA and to identify predictive factors of outcome. Methods: In this multicenter retrospective study, the rates of technique efficacy, regrowth, and retreatment were evaluated in 406 patients treated with either RFA or LA, and followed for 5 years after initial treatment. Propensity score matching was used to compare treatments. Cumulative incidence studies with hazard models were used to describe regrowth and retreatment trends, and to identify prognostic factors. Logistic regression models and receiver operating characteristic analyses were used for risk factors and their cutoffs. Results: RFA and LA significantly reduced benign thyroid nodule volume, and this reduction was generally maintained for 5 years. Technique efficacy (defined as a reduction ≥50% after 1 year from the treatment) was achieved in 74% of patients (85% in the RFA and 63% in the LA group). Regrowth occurred in 28% of patients (20% in the RFA and 38% in the LA group). In the majority of cases, further treatment was not required as only 18% of patients were retreated (12% in the RFA and 24% in the LA group). These data were confirmed by propensity score matching. Cumulative incidence studies showed that RFA was associated with a lower risk of regrowth and a lower risk of requiring retreatment over time. Overall, technique inefficacy and regrowth were associated with low-energy delivery. Retreatments were more frequent in young patients, in large nodules, in patients with lower volume reduction at 1 year, and in cases of low-energy delivery (optimal cutoff was 918 J/mL for RFA). Conclusions: Both thermal ablation techniques result in a clinically significant and long-lasting volume reduction of benign thyroid nodules. The risk of regrowth and needing retreatment was lower after RFA. The need for retreatment was associated with young age, large baseline volume, and treatment with low-energy delivery. Copyright © 2020 Mary Ann Liebert, Inc.
AB - Background: Radiofrequency ablation (RFA) and laser ablation (LA) are effective treatments for benign thyroid nodules. Due to their relatively recent introduction into clinical practice, there are limited long-term follow-up studies. This study aimed to evaluate technique efficacy, rate of regrowth, and retreatment over 5 years after RFA or LA and to identify predictive factors of outcome. Methods: In this multicenter retrospective study, the rates of technique efficacy, regrowth, and retreatment were evaluated in 406 patients treated with either RFA or LA, and followed for 5 years after initial treatment. Propensity score matching was used to compare treatments. Cumulative incidence studies with hazard models were used to describe regrowth and retreatment trends, and to identify prognostic factors. Logistic regression models and receiver operating characteristic analyses were used for risk factors and their cutoffs. Results: RFA and LA significantly reduced benign thyroid nodule volume, and this reduction was generally maintained for 5 years. Technique efficacy (defined as a reduction ≥50% after 1 year from the treatment) was achieved in 74% of patients (85% in the RFA and 63% in the LA group). Regrowth occurred in 28% of patients (20% in the RFA and 38% in the LA group). In the majority of cases, further treatment was not required as only 18% of patients were retreated (12% in the RFA and 24% in the LA group). These data were confirmed by propensity score matching. Cumulative incidence studies showed that RFA was associated with a lower risk of regrowth and a lower risk of requiring retreatment over time. Overall, technique inefficacy and regrowth were associated with low-energy delivery. Retreatments were more frequent in young patients, in large nodules, in patients with lower volume reduction at 1 year, and in cases of low-energy delivery (optimal cutoff was 918 J/mL for RFA). Conclusions: Both thermal ablation techniques result in a clinically significant and long-lasting volume reduction of benign thyroid nodules. The risk of regrowth and needing retreatment was lower after RFA. The need for retreatment was associated with young age, large baseline volume, and treatment with low-energy delivery. Copyright © 2020 Mary Ann Liebert, Inc.
KW - 5 years
KW - benign thyroid nodules
KW - cumulative incidence
KW - follow-up
KW - laser
KW - regrowth
KW - retreatment
KW - RFA
U2 - 10.1089/thy.2020.0202
DO - 10.1089/thy.2020.0202
M3 - Article
VL - 30
SP - 1759
EP - 1770
JO - Thyroid
JF - Thyroid
SN - 1050-7256
IS - 12
ER -