Five-year results of the BEGEV salvage regimen in relapsed/refractory classical Hodgkin lymphoma

A. Santoro, R. Mazza, A. Pulsoni, A. Re, M. Bonfichi, V.R. Zilioli, M. Zanni, F. Merli, A. Anastasia, S. Luminari, G. Annechini, M. Gotti, A. Peli, A.M. Liberati, N. Di Renzo, L. Castagna, L. Giordano, F. Ricci, C. Carlo-Stella

Research output: Contribution to journalArticlepeer-review

Abstract

The complete remission (CR) rate achieved with induction chemotherapy prior to autologous stem cell transplantation (ASCT) represents the strongest prognostic factor in relapsed/ refractory (R/R) classical Hodgkin lymphoma (cHL). By inducing a CR rate of 75%, the bendamustine, gemcitabine, vinorelbine (BEGEV) regimen represents an optimal chemotherapy regimen prior to ASCT. Presented here are the 5-year results of BEGEV followed by ASCT in R/R cHL. With a median follow-up of 5 years, progression-free survival (PFS) and overall survival (OS) for the whole series (n 5 59) were 59% and 78%, respectively. ASCT was performed in 43 of 49 responding patients (73% by intention to treat [ITT]; 88% by response to BEGEV) and resulted in 33 with continuous CR (56% by ITT; 77% of transplanted patients), 7 with disease relapse, and 3 with nonrelapse mortality. For patients who received transplants, the 5-year PFS and OS were 77% and 91%, respectively, with no significant difference between relapsed and refractory patients. No patient experienced secondary leukemia or myelodysplasia. In summary, the long-term efficacy data, the benefits for both relapsed and refractory patients, and the excellent safety profile provide a strong rationale for further development of the BEGEV regimen. © 2020 by The American Society of Hematology.
Original languageEnglish
Pages (from-to)136-140
Number of pages5
JournalBlood Adv.
Volume4
Issue number1
DOIs
Publication statusPublished - 2020

Keywords

  • bendamustine
  • gemcitabine
  • vinorelbine tartrate
  • Article
  • autologous stem cell transplantation
  • cancer combination chemotherapy
  • cancer mortality
  • cancer recurrence
  • cancer survival
  • classical Hodgkin lymphoma
  • drug efficacy
  • drug safety
  • female
  • follow up
  • human
  • leukemia relapse
  • long term care
  • major clinical study
  • male
  • multiple cycle treatment
  • outcome assessment
  • overall survival
  • priority journal
  • progression free survival
  • risk benefit analysis
  • salvage therapy
  • survival time
  • treatment duration

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