Fixed combination of manidipine and delapril in the treatment of mild to moderate essential hypertension: Evaluation by 24-hour ambulatory blood pressure monitoring

Amedeo Mugellini, Alvaro Vaccarella, Aldo Celentano, Flavio Scanferla, Annalisa Zoppi, Roberto Fogari

Research output: Contribution to journalArticle


This present study assessed the antihypertensive efficacy of the fixed combination of manidipine and delapril by ambulatory blood pressure monitoring in patients with hypertension inadequately controlled by monotherapy with either component. After a 2-week placebo period, 55 mild to moderate hypertensive patients were randomized to manidipine 20 mg o.d. or delapril 30 mg b.i.d for 4 weeks. After this period, 30 patients, aged 30-76 years (18 males and 12 females) whose diastolic blood pressure was not adequately controlled (≥90 mmHg) by monotheraphy were treated with fixed combination of manidipine 10 mg plus delapril 30 mg o.d. for 8 weeks. A 24-h ambulatory blood pressure monitoring recording was performed at the end of the placebo washout, of the monotherapy and of the combination therapy. Blood pressure control over the 24 h was quantified by the trough-to-peak ratio and the smoothness index. As compared to placebo, the fixed combination of manidipine and delapril produced to a statistically significant (p

Original languageEnglish
Pages (from-to)6-13
Number of pages8
JournalBlood Pressure
Issue numberSUPPL.1
Publication statusPublished - Jul 2005



  • Ambulatory blood pressure
  • Combination treatment
  • Delapril
  • Essential hypertension
  • Manidipine

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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