Fixed-combination therapies in hypertension management: Focus on enalapril/lercanidipine

Giuliano Tocci, Francesca Palano, Erika Pagannone, Diana Chin, Andrea Ferrucci, Massimo Volpe

Research output: Contribution to journalArticle


Recent hypertension guidelines have highlighted the need to achieve blood pressure control in order to effectively reduce cardiovascular and renal morbidity and mortality. However, blood pressure control remains poorly achieved in the general population, particularly in high- or very-high-risk hypertensive patients. In view of the growing need to achieve better blood pressure control and provide adequate cardiovascular and renal protection in hypertensive patients, the implementation of combination therapies - especially fixed-dose combinations - is currently recommended. A greater use of fixed-combination therapies, based on a single daily administration of two drugs, in fact, may favor better compliance and adherence to prescribed antihypertensive medications. Among the possible fixed-dose combinations, the one based on angiotensin-converting enzyme inhibitors and calcium-channel blockers, may be considered an effective, safe and well-tolerated approach and may provide a beneficial impact on cardiovascular risk. This article reviews the potential role of fixed-combination therapy in the treatment of hypertension with a specific focus on an emerging calcium-channel blocker angiotensin-converting enzyme inhibitor fixed-dose combination based on a new-generation dihiidropiridinic calcium-channel blocker (lercanidipine) and the prototype angiotensin-converting enzyme inhibitor (enalapril).

Original languageEnglish
Pages (from-to)115-123
Number of pages9
JournalExpert Review of Cardiovascular Therapy
Issue number2
Publication statusPublished - Feb 2009


  • Cardiovascular risk
  • Enalapril
  • Fixed-combination therapy
  • Hypertension
  • Lercanidipine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

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