Fixed-combination therapy to improve blood pressure control: Experience with olmesartan-based therapy

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1 Citation (Scopus)

Abstract

Effective treatment of high blood pressure represents a key strategy for reducing the burden of hypertension-related cardiovascular diseases. In spite of these well-established concepts, hypertension remains poorly controlled worldwide. In addition, treated hypertensive patients often remain at higher risk compared with the normotensive population, even when a satisfactory blood pressure control is achieved, owing to a high or very high added cardiovascular risk profile. An emerging strategy to improve blood pressure control in hypertensive patients is a more extensive use of combination therapy than monotherapy in the daily clinical practice. Within the possible antihypertensive drug combinations currently available for the clinical management of hypertension, those based on the association of drugs inhibiting the renin-angiotensin system and thiazide diuretics or calcium channel-blockers have demonstrated to be effective and safe in lowering both systolic and diastolic blood pressure levels with a good tolerability profile. This article provides an overview of fixed-combination strategies, with a particular focus on the fixed-combination strategies based on olmesartan medoxomil.

Original languageEnglish
Pages (from-to)829-840
Number of pages12
JournalExpert Review of Cardiovascular Therapy
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Blood Pressure
Hypertension
Sodium Chloride Symporter Inhibitors
Calcium Channel Blockers
Drug Combinations
Therapeutics
Renin-Angiotensin System
Antihypertensive Agents
Cardiovascular Diseases
olmesartan
Pharmaceutical Preparations
Population
Olmesartan Medoxomil

Keywords

  • amlodipine besylate
  • antihypertensive therapy
  • blood pressure control
  • calcium-channel blocker
  • fixed-combination therapy
  • hypertension
  • olmesartan medoxomil
  • thiazide diuretic

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

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abstract = "Effective treatment of high blood pressure represents a key strategy for reducing the burden of hypertension-related cardiovascular diseases. In spite of these well-established concepts, hypertension remains poorly controlled worldwide. In addition, treated hypertensive patients often remain at higher risk compared with the normotensive population, even when a satisfactory blood pressure control is achieved, owing to a high or very high added cardiovascular risk profile. An emerging strategy to improve blood pressure control in hypertensive patients is a more extensive use of combination therapy than monotherapy in the daily clinical practice. Within the possible antihypertensive drug combinations currently available for the clinical management of hypertension, those based on the association of drugs inhibiting the renin-angiotensin system and thiazide diuretics or calcium channel-blockers have demonstrated to be effective and safe in lowering both systolic and diastolic blood pressure levels with a good tolerability profile. This article provides an overview of fixed-combination strategies, with a particular focus on the fixed-combination strategies based on olmesartan medoxomil.",
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