FK-506 prevents diabetes in diabetes-prone BB/Wor rats

Ferdinando Nicoletti, Pier Luigi Meroni, Wilma Barcellini, Sebastiano Grasso, Mario Orietta Borghi, Michele Lunett, Roberto Di Marco, Stefania Stefani, Lanfranco Mughini

Research output: Contribution to journalArticlepeer-review


The effect of the immunosuppressant FK-506 on the development of diabetes in BB/Wor rats was investigated. Using a treatment schedule (25 μg i.m. from day 27 to 120), not associated with detectable general ill effects, this drug was found to completely inhibit the appearance hyperglycemia and to reduce the histological signs of pancreatic insulitis. The treatment was also able to reduce the percentages of Ia + T-lymphocytes and to block the appearance of detectable serum levels of gamma interferon (IFN).

Original languageEnglish
Pages (from-to)1027-1030
Number of pages4
JournalInternational Journal of Immunopharmacology
Issue number7
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Immunology
  • Pharmacology


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