FLASH is an essential component of Cajal bodies

D. Barcaroli, D. Dinsdale, M. H. Neale, L. Bongiorno-Borbone, M. Ranalli, E. Munarriz, A. E. Sayan, J. M. McWilliam, T. M. Smith, E. Fava, R. A. Knight, G. Melino, V. De Laurenzi

Research output: Contribution to journalArticlepeer-review

Abstract

Cajal bodies are small nuclear organelles with a number of nuclear functions. Here we show that FLICE-associated huge protein (FLASH), originally described as a component of the apoptosis signaling pathway, is mainly localized in Cajal bodies and is essential for their structure. Reduction in FLASH expression by short hairpin RNA results in disruption of the normal architecture of the Cajal body and relocalization of its components. Because the function of FLASH in the apoptosis receptor signaling pathway has been strongly questioned, we have now identified a clear function for this protein.

Original languageEnglish
Pages (from-to)14802-14807
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number40
DOIs
Publication statusPublished - Oct 3 2006

Keywords

  • Coiled bodies
  • Nuclear organelles

ASJC Scopus subject areas

  • Genetics
  • General

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