Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

R. Zamora-Ros, C. Sacerdote, F. Ricceri, E. Weiderpass, N. Roswall, G. Buckland, D. E. St-Jules, K. Overvad, C. Kyrø, G. Fagherazzi, M. Kvaskoff, G. Severi, J. Chang-Claude, R. Kaaks, U. Nöthlings, A. Trichopoulou, A. Naska, D. Trichopoulos, D. Palli, S. GrioniA. Mattiello, R. Tumino, I. T. Gram, D. Engeset, J. M. Huerta, E. Molina-Montes, M. Argüelles, P. Amiano, E. Ardanaz, U. Ericson, B. Lindkvist, L. M. Nilsson, L. A. Kiemeney, M. Ros, H. B. Bueno-De-Mesquita, P. H M Peeters, K. T. Khaw, N. J. Wareham, V. Knaze, I. Romieu, A. Scalbert, P. Brennan, P. Wark, P. Vineis, E. Riboli, C. A. González

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background:There is growing evidence of the protective role of dietary intake of flavonoids and lignans on cancer, but the association with bladder cancer has not been thoroughly investigated in epidemiological studies. We evaluated the association between dietary intakes of total and subclasses of flavonoids and lignans and risk of bladder cancer and its main morphological type, urothelial cell carcinoma (UCC), within the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:A cohort of 477 312 men and women mostly aged 35-70 years, were recruited in 10 European countries. At baseline, dietary flavonoid and lignan intakes were estimated using centre-specific validated questionnaires and a food composition database based on the Phenol-Explorer, the UK Food Standards Agency and the US Department of Agriculture databases.Results:During an average of 11 years of follow-up, 1575 new cases of primary bladder cancer were identified, of which 1425 were UCC (classified into aggressive (n=430) and non-aggressive (n=413) UCC). No association was found between total flavonoid intake and bladder cancer risk. Among flavonoid subclasses, significant inverse associations with bladder cancer risk were found for intakes of flavonol (hazard ratio comparing fifth with first quintile (HR Q5-Q1) 0.74, 95% confidence interval (CI): 0.61-0.91; P-trend=0.009) and lignans (HR Q5-Q1 0.78, 95% CI: 0.62-0.96; P-trend=0.046). Similar results were observed for overall UCC and aggressive UCC, but not for non-aggressive UCC.Conclusions:Our study suggests an inverse association between the dietary intakes of flavonols and lignans and risk of bladder cancer, particularly aggressive UCC.

Original languageEnglish
Pages (from-to)1870-1880
Number of pages11
JournalBritish Journal of Cancer
Volume111
Issue number9
DOIs
Publication statusPublished - Oct 28 2014

Fingerprint

Lignans
Flavonoids
Urinary Bladder Neoplasms
Carcinoma
Neoplasms
Databases
Confidence Intervals
Food
United States Department of Agriculture
Flavonols
Phenol
Epidemiologic Studies

Keywords

  • bladder cancer
  • dietary intake
  • EPIC
  • flavonoids
  • lignans

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Zamora-Ros, R., Sacerdote, C., Ricceri, F., Weiderpass, E., Roswall, N., Buckland, G., ... González, C. A. (2014). Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. British Journal of Cancer, 111(9), 1870-1880. https://doi.org/10.1038/bjc.2014.459

Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. / Zamora-Ros, R.; Sacerdote, C.; Ricceri, F.; Weiderpass, E.; Roswall, N.; Buckland, G.; St-Jules, D. E.; Overvad, K.; Kyrø, C.; Fagherazzi, G.; Kvaskoff, M.; Severi, G.; Chang-Claude, J.; Kaaks, R.; Nöthlings, U.; Trichopoulou, A.; Naska, A.; Trichopoulos, D.; Palli, D.; Grioni, S.; Mattiello, A.; Tumino, R.; Gram, I. T.; Engeset, D.; Huerta, J. M.; Molina-Montes, E.; Argüelles, M.; Amiano, P.; Ardanaz, E.; Ericson, U.; Lindkvist, B.; Nilsson, L. M.; Kiemeney, L. A.; Ros, M.; Bueno-De-Mesquita, H. B.; Peeters, P. H M; Khaw, K. T.; Wareham, N. J.; Knaze, V.; Romieu, I.; Scalbert, A.; Brennan, P.; Wark, P.; Vineis, P.; Riboli, E.; González, C. A.

In: British Journal of Cancer, Vol. 111, No. 9, 28.10.2014, p. 1870-1880.

Research output: Contribution to journalArticle

Zamora-Ros, R, Sacerdote, C, Ricceri, F, Weiderpass, E, Roswall, N, Buckland, G, St-Jules, DE, Overvad, K, Kyrø, C, Fagherazzi, G, Kvaskoff, M, Severi, G, Chang-Claude, J, Kaaks, R, Nöthlings, U, Trichopoulou, A, Naska, A, Trichopoulos, D, Palli, D, Grioni, S, Mattiello, A, Tumino, R, Gram, IT, Engeset, D, Huerta, JM, Molina-Montes, E, Argüelles, M, Amiano, P, Ardanaz, E, Ericson, U, Lindkvist, B, Nilsson, LM, Kiemeney, LA, Ros, M, Bueno-De-Mesquita, HB, Peeters, PHM, Khaw, KT, Wareham, NJ, Knaze, V, Romieu, I, Scalbert, A, Brennan, P, Wark, P, Vineis, P, Riboli, E & González, CA 2014, 'Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study', British Journal of Cancer, vol. 111, no. 9, pp. 1870-1880. https://doi.org/10.1038/bjc.2014.459
Zamora-Ros, R. ; Sacerdote, C. ; Ricceri, F. ; Weiderpass, E. ; Roswall, N. ; Buckland, G. ; St-Jules, D. E. ; Overvad, K. ; Kyrø, C. ; Fagherazzi, G. ; Kvaskoff, M. ; Severi, G. ; Chang-Claude, J. ; Kaaks, R. ; Nöthlings, U. ; Trichopoulou, A. ; Naska, A. ; Trichopoulos, D. ; Palli, D. ; Grioni, S. ; Mattiello, A. ; Tumino, R. ; Gram, I. T. ; Engeset, D. ; Huerta, J. M. ; Molina-Montes, E. ; Argüelles, M. ; Amiano, P. ; Ardanaz, E. ; Ericson, U. ; Lindkvist, B. ; Nilsson, L. M. ; Kiemeney, L. A. ; Ros, M. ; Bueno-De-Mesquita, H. B. ; Peeters, P. H M ; Khaw, K. T. ; Wareham, N. J. ; Knaze, V. ; Romieu, I. ; Scalbert, A. ; Brennan, P. ; Wark, P. ; Vineis, P. ; Riboli, E. ; González, C. A. / Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. In: British Journal of Cancer. 2014 ; Vol. 111, No. 9. pp. 1870-1880.
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abstract = "Background:There is growing evidence of the protective role of dietary intake of flavonoids and lignans on cancer, but the association with bladder cancer has not been thoroughly investigated in epidemiological studies. We evaluated the association between dietary intakes of total and subclasses of flavonoids and lignans and risk of bladder cancer and its main morphological type, urothelial cell carcinoma (UCC), within the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:A cohort of 477 312 men and women mostly aged 35-70 years, were recruited in 10 European countries. At baseline, dietary flavonoid and lignan intakes were estimated using centre-specific validated questionnaires and a food composition database based on the Phenol-Explorer, the UK Food Standards Agency and the US Department of Agriculture databases.Results:During an average of 11 years of follow-up, 1575 new cases of primary bladder cancer were identified, of which 1425 were UCC (classified into aggressive (n=430) and non-aggressive (n=413) UCC). No association was found between total flavonoid intake and bladder cancer risk. Among flavonoid subclasses, significant inverse associations with bladder cancer risk were found for intakes of flavonol (hazard ratio comparing fifth with first quintile (HR Q5-Q1) 0.74, 95{\%} confidence interval (CI): 0.61-0.91; P-trend=0.009) and lignans (HR Q5-Q1 0.78, 95{\%} CI: 0.62-0.96; P-trend=0.046). Similar results were observed for overall UCC and aggressive UCC, but not for non-aggressive UCC.Conclusions:Our study suggests an inverse association between the dietary intakes of flavonols and lignans and risk of bladder cancer, particularly aggressive UCC.",
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TY - JOUR

T1 - Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

AU - Zamora-Ros, R.

AU - Sacerdote, C.

AU - Ricceri, F.

AU - Weiderpass, E.

AU - Roswall, N.

AU - Buckland, G.

AU - St-Jules, D. E.

AU - Overvad, K.

AU - Kyrø, C.

AU - Fagherazzi, G.

AU - Kvaskoff, M.

AU - Severi, G.

AU - Chang-Claude, J.

AU - Kaaks, R.

AU - Nöthlings, U.

AU - Trichopoulou, A.

AU - Naska, A.

AU - Trichopoulos, D.

AU - Palli, D.

AU - Grioni, S.

AU - Mattiello, A.

AU - Tumino, R.

AU - Gram, I. T.

AU - Engeset, D.

AU - Huerta, J. M.

AU - Molina-Montes, E.

AU - Argüelles, M.

AU - Amiano, P.

AU - Ardanaz, E.

AU - Ericson, U.

AU - Lindkvist, B.

AU - Nilsson, L. M.

AU - Kiemeney, L. A.

AU - Ros, M.

AU - Bueno-De-Mesquita, H. B.

AU - Peeters, P. H M

AU - Khaw, K. T.

AU - Wareham, N. J.

AU - Knaze, V.

AU - Romieu, I.

AU - Scalbert, A.

AU - Brennan, P.

AU - Wark, P.

AU - Vineis, P.

AU - Riboli, E.

AU - González, C. A.

PY - 2014/10/28

Y1 - 2014/10/28

N2 - Background:There is growing evidence of the protective role of dietary intake of flavonoids and lignans on cancer, but the association with bladder cancer has not been thoroughly investigated in epidemiological studies. We evaluated the association between dietary intakes of total and subclasses of flavonoids and lignans and risk of bladder cancer and its main morphological type, urothelial cell carcinoma (UCC), within the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:A cohort of 477 312 men and women mostly aged 35-70 years, were recruited in 10 European countries. At baseline, dietary flavonoid and lignan intakes were estimated using centre-specific validated questionnaires and a food composition database based on the Phenol-Explorer, the UK Food Standards Agency and the US Department of Agriculture databases.Results:During an average of 11 years of follow-up, 1575 new cases of primary bladder cancer were identified, of which 1425 were UCC (classified into aggressive (n=430) and non-aggressive (n=413) UCC). No association was found between total flavonoid intake and bladder cancer risk. Among flavonoid subclasses, significant inverse associations with bladder cancer risk were found for intakes of flavonol (hazard ratio comparing fifth with first quintile (HR Q5-Q1) 0.74, 95% confidence interval (CI): 0.61-0.91; P-trend=0.009) and lignans (HR Q5-Q1 0.78, 95% CI: 0.62-0.96; P-trend=0.046). Similar results were observed for overall UCC and aggressive UCC, but not for non-aggressive UCC.Conclusions:Our study suggests an inverse association between the dietary intakes of flavonols and lignans and risk of bladder cancer, particularly aggressive UCC.

AB - Background:There is growing evidence of the protective role of dietary intake of flavonoids and lignans on cancer, but the association with bladder cancer has not been thoroughly investigated in epidemiological studies. We evaluated the association between dietary intakes of total and subclasses of flavonoids and lignans and risk of bladder cancer and its main morphological type, urothelial cell carcinoma (UCC), within the European Prospective Investigation into Cancer and Nutrition (EPIC) study.Methods:A cohort of 477 312 men and women mostly aged 35-70 years, were recruited in 10 European countries. At baseline, dietary flavonoid and lignan intakes were estimated using centre-specific validated questionnaires and a food composition database based on the Phenol-Explorer, the UK Food Standards Agency and the US Department of Agriculture databases.Results:During an average of 11 years of follow-up, 1575 new cases of primary bladder cancer were identified, of which 1425 were UCC (classified into aggressive (n=430) and non-aggressive (n=413) UCC). No association was found between total flavonoid intake and bladder cancer risk. Among flavonoid subclasses, significant inverse associations with bladder cancer risk were found for intakes of flavonol (hazard ratio comparing fifth with first quintile (HR Q5-Q1) 0.74, 95% confidence interval (CI): 0.61-0.91; P-trend=0.009) and lignans (HR Q5-Q1 0.78, 95% CI: 0.62-0.96; P-trend=0.046). Similar results were observed for overall UCC and aggressive UCC, but not for non-aggressive UCC.Conclusions:Our study suggests an inverse association between the dietary intakes of flavonols and lignans and risk of bladder cancer, particularly aggressive UCC.

KW - bladder cancer

KW - dietary intake

KW - EPIC

KW - flavonoids

KW - lignans

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