TY - JOUR
T1 - Flavonoid supplements increase neurotrophin activity to modulate inflammation in retinal genetic diseases
AU - Kiani, Aysha Karim
AU - Falsini, Benedetto
AU - Ziccardi, Lucia
AU - Gusson, Elena
AU - Mangialavori, Domenica
AU - Allegrini, Francesca
AU - Colao, Emma
AU - Bertelli, Matteo
N1 - Funding Information:
The contribution of Fondazione Bietti in this paper was supported by the Ministry of Health and Fon-dazione Roma.
Publisher Copyright:
© Mattioli 1885.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Retinal degenerative disorders induce loss of photoreceptors associated with inflammation, and negative remodeling and plasticity of neural retina. Retinal degenerative diseases may have genetic and/or environmental causes. Degeneration of retinal pigment epithelium cells initiates a vicious circle increasing the ongoing inflammation in both retina and choroid. Flavonoids are polyphenolic molecules with antioxidant activity and dietary intake, specifically of anthocyanins and flavanols, improves oxidative stress and neuro-in-flammation. In vitro and ex vivo studies have also revealed biological effects of flavonoids on retinal protection against oxidative stress and inflammation. In this brief review, the protective role of flavonoids against retinal degeneration and inflammation will be discussed along with their therapeutic potential for the treatment of retinal degenerative diseases. (www.actabiomedica.it).
AB - Retinal degenerative disorders induce loss of photoreceptors associated with inflammation, and negative remodeling and plasticity of neural retina. Retinal degenerative diseases may have genetic and/or environmental causes. Degeneration of retinal pigment epithelium cells initiates a vicious circle increasing the ongoing inflammation in both retina and choroid. Flavonoids are polyphenolic molecules with antioxidant activity and dietary intake, specifically of anthocyanins and flavanols, improves oxidative stress and neuro-in-flammation. In vitro and ex vivo studies have also revealed biological effects of flavonoids on retinal protection against oxidative stress and inflammation. In this brief review, the protective role of flavonoids against retinal degeneration and inflammation will be discussed along with their therapeutic potential for the treatment of retinal degenerative diseases. (www.actabiomedica.it).
KW - Anti-inflamation
KW - Anti-oxidant
KW - Flavonoids supplementation
KW - Neurotrophin synthesis
KW - Retinal degenerative disorders
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U2 - 10.23750/abm.v91i13-S.10683
DO - 10.23750/abm.v91i13-S.10683
M3 - Review article
C2 - 33170164
AN - SCOPUS:85096079906
VL - 91
SP - 1
EP - 5
JO - Acta Biomedica de l'Ateneo Parmense
JF - Acta Biomedica de l'Ateneo Parmense
SN - 0392-4203
M1 - e2020014
ER -