Flavonoids acting on DNA topoisomerases: Recent advances and future perspectives in cancer therapy

P. Russo, A. Del Bufalo, A. Cesario

Research output: Contribution to journalArticlepeer-review

Abstract

Flavonoids, secondary metabolites ubiquitously produced in the plant kingdom, are low molecular weight polyphenolic molecules. They are characterized by variable chemical structures and show a vast array of biological activities (i.e.. antiviral, antiinflammatory, antitumor, antimicrobial, estrogenic, antiestrogenic, antioxidant, mutagenic and antimutagenic) targeting different pathways. Some of these compounds such as Genistein, Daidzein or its synthetic derivative Phenoxodiol as well as Luteolin and Quercetin are able to inhibit DNA topoisomerases. This review discusses that Flavonoids targeting DNA topoisomerases may lead to novel drug development with anticancer potential.

Original languageEnglish
Pages (from-to)5287-5293
Number of pages7
JournalCurrent Medicinal Chemistry
Volume19
Issue number31
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Cell death
  • Clinical trials
  • DNA topoisomerases
  • DNA topoisomerases poisoning
  • Drug discovery and development
  • Flavonoids
  • Phenoxodiol
  • Systems Biology

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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