Flavonoids and bladder cancer risk

Marta Rossi, Panagiota Strikoudi, Maria Eleni Spei, Maria Parpinel, Diego Serraino, Maurizio Montella, Massimo Libra, Carlo La Vecchia, Valentina Rosato

Research output: Contribution to journalArticlepeer-review


Purpose: Flavonoids have drawn attention because of their antioxidant capacity and anti-carcinogenic effect in various types of cancer. A limited number of studies has investigated their potential effect on the risk of bladder cancer, with inconsistent results. Methods: We analyzed data from an Italian case–control study including 690 incident bladder cancer cases and 665 controls admitted to the same network of hospitals for acute, non-neoplastic, non tobacco-related diseases. Subjects were interviewed using a reproducible and validated food-frequency questionnaire. We applied data on food and beverage composition to estimate the intake of isoflavones, anthocyanidins, flavan-3-ols, flavanones, flavones and flavonols. We estimated odds ratios (ORs) through multiple logistic regression models, including terms for potential confounding factors, including tobacco smoking and total energy intake. Results: We found an inverse association between isoflavones (OR for the highest compared to the lowest quintile of intake = 0.56, 95% CI 0.37–0.84) and flavones (OR = 0.64, 95% CI 0.44–0.95) and bladder cancer. Non-significant inverse association was found for flavan-3-ols (OR = 0.70), flavonols (OR = 0.85) and total flavonoids (OR = 0.76). The results were consistent for non-muscle-invasive and muscle-invasive bladder cancers. Conclusions: Our data indicate an inverse association between isoflavones and flavones with respect to bladder cancer risk.

Original languageEnglish
JournalCancer Causes and Control
Publication statusPublished - Jan 1 2019


  • Bladder cancer
  • Case–control study
  • Flavonoids
  • Risk factors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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