Flavonoids and colorectal cancer in italy

Marta Rossi, Eva Negri, Renato Talamini, Cristina Bosetti, Maria Parpinel, Patrizia Gnagnarella, Silvia Franceschi, Luigino Dal Maso, Maurizio Montella, Attilio Giacosa, Carlo La Vecchia

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Because of their several biological activities, flavonoids may have an important role in explaining the protective effects of vegetables, fruit, and, possibly, tea against cancer. The potential relation between flavonoids and colorectal cancer risk was investigated using data from a multicentric Italian case-control study, including 1,953 cases of colorectal cancers (1,225 colon cancers and 728 rectal cancers) and 4,154 hospital controls admitted for acute nonneoplastic diseases. We have applied recently published data on the composition of foods and beverages, in terms of six principal classes of flavonoids, on dietary information collected through a validated food-frequency questionnaire. Odds ratios (OR) were estimated by multiple logistic regression models, including terms for sex, age, study center, family history of colorectal cancer, education, alcohol consumption, body mass index, physical activity, and energy intake. A reduced risk of colorectal cancer was found for increasing intake of isoflavones (OR, 0.76, for the highest versus the lowest quintile, P trend = 0.001), anthocyanidins (OR, 0.67, P trend <0.001), flavones (OR, 0.78, P trend = 0.004), and flavonols (OR, 0.64, P trend <0.001). No significant association was found for flavan-3-ols (OR, 0.98), flavanones (OR, 0.96), and total flavonoids (OR, 0.97). The estimates did not substantially differ for colon and rectal cancers, as well as in strata of sex, age, and body mass index. The findings of this large study provide support for an inverse association of selected classes of flavonoids with colorectal cancer risk.

Original languageEnglish
Pages (from-to)1555-1558
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Volume15
Issue number8
DOIs
Publication statusPublished - Aug 2006

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Flavonoids
Italy
Colorectal Neoplasms
Odds Ratio
Rectal Neoplasms
Colonic Neoplasms
Body Mass Index
Logistic Models
Flavanones
Flavones
Food and Beverages
Flavonols
Isoflavones
Anthocyanins
Acute Disease
Tea
Energy Intake
Alcohol Drinking
Vegetables
Case-Control Studies

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Flavonoids and colorectal cancer in italy. / Rossi, Marta; Negri, Eva; Talamini, Renato; Bosetti, Cristina; Parpinel, Maria; Gnagnarella, Patrizia; Franceschi, Silvia; Dal Maso, Luigino; Montella, Maurizio; Giacosa, Attilio; La Vecchia, Carlo.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 15, No. 8, 08.2006, p. 1555-1558.

Research output: Contribution to journalArticle

Rossi, M, Negri, E, Talamini, R, Bosetti, C, Parpinel, M, Gnagnarella, P, Franceschi, S, Dal Maso, L, Montella, M, Giacosa, A & La Vecchia, C 2006, 'Flavonoids and colorectal cancer in italy', Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 8, pp. 1555-1558. https://doi.org/10.1158/1055-9965.EPI-06-0017
Rossi, Marta ; Negri, Eva ; Talamini, Renato ; Bosetti, Cristina ; Parpinel, Maria ; Gnagnarella, Patrizia ; Franceschi, Silvia ; Dal Maso, Luigino ; Montella, Maurizio ; Giacosa, Attilio ; La Vecchia, Carlo. / Flavonoids and colorectal cancer in italy. In: Cancer Epidemiology Biomarkers and Prevention. 2006 ; Vol. 15, No. 8. pp. 1555-1558.
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