Flavonoids and ovarian cancer risk: A case-control study in Italy

Marta Rossi, Eva Negri, Pagona Lagiou, Renato Talamini, Luigino Dal Maso, Maurizio Montella, Silvia Franceschi, Carlo La Vecchia

Research output: Contribution to journalArticlepeer-review


Flavonoids belong to a vast group of polyphenols widely distributed in all foods of plant origin. Because of their antioxidant, antimutagenic and antiproliferative properties, they have been hypothesized to contribute to the favorable effects of fruit and vegetables against cancer. The aim of this study is to investigate the relation of 6 classes of flavonoids (flavan-3-ols, flavanones, flavonols, flavones, anthocyanidins and isoflavones) with ovarian cancer risk, using data from a multicentric case-control study conducted in Italy between 1992 and 1999. The study included 1,031 cases with incident, histologically confirmed epithelial ovarian cancer and 2,411 controls admitted for acute, nonneoplastic conditions to major hospitals in the same catchment areas. In logistic regression models including study center, education, year of interview, parity, oral contraceptive use and family history of ovarian or breast cancer or both, an inverse relation with significant trend in risk was found between ovarian cancer and flavonols [odds ratio (OR), 0.63; 95% confidence intervals (CI) 0.47-0.84] as well as isoflavones (OR, 0.51; 95% CI, 0.37-0.69), comparing the highest versus the lowest quintile. Further adjustment for fruit and vegetable intake did not modify these associations, suggesting that isoflavones and flavonols may have a distinct role in explaining the effect of fruit and vegetable against ovarian cancer. On the basis of our findings and the relevant literature, we infer that isoflavones, and perhaps flavonols, may have favorable effects with respect to ovarian cancer risk.

Original languageEnglish
Pages (from-to)895-898
Number of pages4
JournalInternational Journal of Cancer
Issue number4
Publication statusPublished - Aug 15 2008


  • Case-control study
  • Flavonoids
  • Isoflavones
  • Ovarian cancer
  • Risk factors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)


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