Flavonoids in Bone Erosive Diseases: Perspectives in Osteoporosis Treatment

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Abstract

Imbalance of bone homeostasis, with excessive bone resorption compared with bone formation, leads to the development of progressive osteopenia leading to lower bone resistance to load, with consequent pain and functional limitations. Phytochemicals with therapeutic and preventive effects against bone resorption have recently received increasing attention since they are potentially more suitable for long-term use than traditional therapeutic chemical compounds. In this systematic review of the literature of the past 5 years, comprehensive information is provided on flavonoids with potential antiresorption and pro-osteogenic effects. It aims to highlight the molecular mechanisms of these molecules, often epigenetic, and their possible pharmacological use, which is of great importance for the prevention and treatment of osteoporosis (OP).

Original languageEnglish
Number of pages19
JournalTrends in Endocrinology and Metabolism
Early online dateDec 4 2020
DOIs
Publication statusPublished - 2021

Keywords

  • bone erosive diseases
  • flavonoids
  • osteoblast
  • osteoclast
  • osteoporosis

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