Flexibility and efficacy of automatic continuous fluorodeoxyuridine infusion in metastases from a renal cell carcinoma

B. Damascelli, A. Marchiano, L. F. Frigerio, M. Salvetti, C. Spreafico, F. Garbagnati, F. Zanoni, F. Radice

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Complete and lasting control of diffuse metastases from a renal cell carcinoma has been achieved by automatic continuous infusion of a single cytotoxic agent, fluorodeoxyuridine (FUDR). A patient with a single brain metastasis from renal cell carcinoma developed pulmonary, mediastinal, and retroperitoneal metastases after radical nephrectomy. A Medtronic Synchromed pump (Medtronic Inc., Minneapolis, MN) was implanted for the circadian systemic infusion of FUDR in 14-day courses with 14-day drug-free intervals. A complete response (CR) at all sites, was obtained in 3 months, and maintained for 22 months. After a second brain metastasis, treated by radiation therapy and cisplatin as radiosensitizer, a CR was obtained again and is now of 31 months' duration, which is four times the record to date. The overall hospitalization was 2 days. Acceptance of the pump is excellent and it functions precisely and reliably. This case should stimulate greater interest in techniques of automatic continuous infusion of cytostatics, given its greater efficacy and lower toxicity.

Original languageEnglish
Pages (from-to)995-998
Number of pages4
JournalCancer
Volume68
Issue number5
DOIs
Publication statusPublished - 1991

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Floxuridine
Renal Cell Carcinoma
Neoplasm Metastasis
Cytotoxins
Brain
Cytostatic Agents
Nephrectomy
Cisplatin
Hospitalization
Radiotherapy
Lung
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Flexibility and efficacy of automatic continuous fluorodeoxyuridine infusion in metastases from a renal cell carcinoma. / Damascelli, B.; Marchiano, A.; Frigerio, L. F.; Salvetti, M.; Spreafico, C.; Garbagnati, F.; Zanoni, F.; Radice, F.

In: Cancer, Vol. 68, No. 5, 1991, p. 995-998.

Research output: Contribution to journalArticle

Damascelli, B. ; Marchiano, A. ; Frigerio, L. F. ; Salvetti, M. ; Spreafico, C. ; Garbagnati, F. ; Zanoni, F. ; Radice, F. / Flexibility and efficacy of automatic continuous fluorodeoxyuridine infusion in metastases from a renal cell carcinoma. In: Cancer. 1991 ; Vol. 68, No. 5. pp. 995-998.
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AU - Spreafico, C.

AU - Garbagnati, F.

AU - Zanoni, F.

AU - Radice, F.

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