Flexible-dose oral paliperidone ER in non-acute schizophrenia previously unsuccessfully treated with oral risperidone

Dieter Naber, Joseph Peuskens, Bruno Millet, Roberto Cavallaro, Mikhail V. Ivanov, Manuel A. Franco, Georgia Doulgeraki, Marjolein Lahaye, Andreas Schreiner

Research output: Contribution to journalArticle

Abstract

Aims: Assessment of oral paliperidone ER therapy. Methods: A subgroup analysis of patients with schizophrenia switched from unsuccessful oral risperidone therapy in a 6-month, open-label, multicenter study investigating flexibly dosed paliperidone ER. Results: 694 patients were analyzed (59.2% male; mean age: 40.0 years). Mean change in PANSS total score from baseline to end point was -14.4 ± 20.2 in patients switching due to lack of efficacy (n = 359). Mean change in PANSS total score for patients switching for other reasons (n = 319) was: -7.6 ± 17.0 (lack of tolerability, n = 175), -19.6 ± 20.3 (lack of compliance, n = 76), and -12.0 ± 16.8 (other, n = 68). Conclusion: In patients with schizophrenia previously unsuccessfully treated with oral risperidone, paliperidone ER was well tolerated and associated with a meaningful treatment response.

Original languageEnglish
Pages (from-to)573-583
Number of pages11
JournalClinical Practice
Volume11
Issue number6
DOIs
Publication statusPublished - Dec 1 2014

Keywords

  • flexible dosing
  • paliperidone
  • risperidone
  • schizophrenia
  • switching

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

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    Naber, D., Peuskens, J., Millet, B., Cavallaro, R., Ivanov, M. V., Franco, M. A., Doulgeraki, G., Lahaye, M., & Schreiner, A. (2014). Flexible-dose oral paliperidone ER in non-acute schizophrenia previously unsuccessfully treated with oral risperidone. Clinical Practice, 11(6), 573-583. https://doi.org/10.2217/cpr.14.75