Flexible-dose oral paliperidone ER in non-acute schizophrenia previously unsuccessfully treated with oral risperidone

Dieter Naber; Joseph Peuskens; Bruno Millet; Roberto Cavallaro; Mikhail V. Ivanov; Manuel A. Franco; Georgia Doulgeraki; Marjolein Lahaye; Andreas Schreiner

doi:10.2217/cpr.14.75

Flexible-dose oral paliperidone ER in non-acute schizophrenia previously unsuccessfully treated with oral risperidone

Dieter Naber, Joseph Peuskens, Bruno Millet, Roberto Cavallaro, Mikhail V. Ivanov, Manuel A. Franco, Georgia Doulgeraki, Marjolein Lahaye, Andreas Schreiner

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article

Abstract

Aims: Assessment of oral paliperidone ER therapy. Methods: A subgroup analysis of patients with schizophrenia switched from unsuccessful oral risperidone therapy in a 6-month, open-label, multicenter study investigating flexibly dosed paliperidone ER. Results: 694 patients were analyzed (59.2% male; mean age: 40.0 years). Mean change in PANSS total score from baseline to end point was -14.4 ± 20.2 in patients switching due to lack of efficacy (n = 359). Mean change in PANSS total score for patients switching for other reasons (n = 319) was: -7.6 ± 17.0 (lack of tolerability, n = 175), -19.6 ± 20.3 (lack of compliance, n = 76), and -12.0 ± 16.8 (other, n = 68). Conclusion: In patients with schizophrenia previously unsuccessfully treated with oral risperidone, paliperidone ER was well tolerated and associated with a meaningful treatment response.

Original language	English
Pages (from-to)	573-583
Number of pages	11
Journal	Clinical Practice
Volume	11
Issue number	6
DOIs	https://doi.org/10.2217/cpr.14.75
Publication status	Published - Dec 1 2014

Keywords

flexible dosing
paliperidone
risperidone
schizophrenia
switching

ASJC Scopus subject areas

Medicine(all)
Pharmacology (medical)

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10.2217/cpr.14.75

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Naber, D., Peuskens, J., Millet, B., Cavallaro, R., Ivanov, M. V., Franco, M. A., Doulgeraki, G., Lahaye, M., & Schreiner, A. (2014). Flexible-dose oral paliperidone ER in non-acute schizophrenia previously unsuccessfully treated with oral risperidone. Clinical Practice, 11(6), 573-583. https://doi.org/10.2217/cpr.14.75

Flexible-dose oral paliperidone ER in non-acute schizophrenia previously unsuccessfully treated with oral risperidone. / Naber, Dieter; Peuskens, Joseph; Millet, Bruno; Cavallaro, Roberto; Ivanov, Mikhail V.; Franco, Manuel A.; Doulgeraki, Georgia; Lahaye, Marjolein; Schreiner, Andreas.

In: Clinical Practice, Vol. 11, No. 6, 01.12.2014, p. 573-583.

Research output: Contribution to journal › Article

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