Abstract
Flow cytometric DNA analysis was performed on formalin-fixed, paraffin-embedded samples obtained by gastroscopic biopsy from 9 patients with histologically normal gastric mucosa (36 specimens) and by radical gastrectomy from 42 cases of human gastric cancer (120 specimens). Ploidy patterns and the distribution of cells in the different cell cycle phases were estimated, and the results were correlated with the histologic and clinical features. All samples of normal mucosa showed a diploid modal DNA content whereas DNA aneuploidy was encountered in 71.4% of the gastric tumors. The correlation between aneuploidy and histologic malignancy grading was statistically significant: aneuploidy was found in 36.4% of highly differentiated (grade 1 and grade 2) tumors and in 75.0% of poorly differentiated (grade 3) tumors (P
| Original language | English |
|---|---|
| Pages (from-to) | 200-206 |
| Number of pages | 7 |
| Journal | Analytical and Quantitative Cytology and Histology |
| Volume | 10 |
| Issue number | 3 |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Cell Biology
- Anatomy
- Histology
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Flow cytometric analysis of paraffin-embedded material in human gastric cancer. / Danova, M.; Riccardi, A.; Mazzini, G.; Wilson, G.; Dionigi, P.; Brugnatelli, S.; Fiocca, R.; Ucci, G.; Jemos, V.; Ascari, E.
In: Analytical and Quantitative Cytology and Histology, Vol. 10, No. 3, 1988, p. 200-206.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Flow cytometric analysis of paraffin-embedded material in human gastric cancer
AU - Danova, M.
AU - Riccardi, A.
AU - Mazzini, G.
AU - Wilson, G.
AU - Dionigi, P.
AU - Brugnatelli, S.
AU - Fiocca, R.
AU - Ucci, G.
AU - Jemos, V.
AU - Ascari, E.
PY - 1988
Y1 - 1988
N2 - Flow cytometric DNA analysis was performed on formalin-fixed, paraffin-embedded samples obtained by gastroscopic biopsy from 9 patients with histologically normal gastric mucosa (36 specimens) and by radical gastrectomy from 42 cases of human gastric cancer (120 specimens). Ploidy patterns and the distribution of cells in the different cell cycle phases were estimated, and the results were correlated with the histologic and clinical features. All samples of normal mucosa showed a diploid modal DNA content whereas DNA aneuploidy was encountered in 71.4% of the gastric tumors. The correlation between aneuploidy and histologic malignancy grading was statistically significant: aneuploidy was found in 36.4% of highly differentiated (grade 1 and grade 2) tumors and in 75.0% of poorly differentiated (grade 3) tumors (P
AB - Flow cytometric DNA analysis was performed on formalin-fixed, paraffin-embedded samples obtained by gastroscopic biopsy from 9 patients with histologically normal gastric mucosa (36 specimens) and by radical gastrectomy from 42 cases of human gastric cancer (120 specimens). Ploidy patterns and the distribution of cells in the different cell cycle phases were estimated, and the results were correlated with the histologic and clinical features. All samples of normal mucosa showed a diploid modal DNA content whereas DNA aneuploidy was encountered in 71.4% of the gastric tumors. The correlation between aneuploidy and histologic malignancy grading was statistically significant: aneuploidy was found in 36.4% of highly differentiated (grade 1 and grade 2) tumors and in 75.0% of poorly differentiated (grade 3) tumors (P
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M3 - Article
C2 - 3408546
AN - SCOPUS:0023937584
VL - 10
SP - 200
EP - 206
JO - Analytical and Quantitative Cytology
JF - Analytical and Quantitative Cytology
SN - 0884-6812
IS - 3
ER -