Flow distribution analysis by helical scanning in polysulfone hemodialyzers: Effects of fiber structure and design on flow patterns and solute clearances

Claudio Ronco, Nathan Levin, Alessandra Brendolan, Federico Nalesso, Dinna Cruz, Catalina Ocampo, Dingway Kuang, Monica Bonello, Massimo De Cal, Valentina Corradi, Zaccaria Ricci

Research output: Contribution to journalArticlepeer-review

Abstract

The efficiency of a hemodialyzer is largely dependent on its ability to facilitate diffusion, as this is the main mechanism by which small solutes are removed. The diffusion process can be impaired if there is a mismatch between blood and dialysate flow distribution in the dialyzer. The objective of the paper was to study the impact of different fiber bundle configurations on blood and dialysate flow distribution and urea clearances. The Optiflux 200 NR hemodialyzer was studied and the standard F 80 A hemodialyzer was used as a control for the study. Six dialyzers of each type were studied in vitro in the radiology department utilizing a new generation of helical computed tomography (CT) scan following contrast medium injection into the blood and dialysate compartment. Dynamic sequential imaging of longitudinal sections of the dialyzer was undertaken to detect flow distribution, average and peak velocities, and calculate wall shear rates. Six patients were dialyzed with 2 different dialyzers in random consecutive sequence. In these patients, 2 consecutive dialyses were carried out with identical operational parameters (Qb=300mL/min, Qd=500mL/min). In each session, blood and dialysate side urea clearances were measured at 30 and 150min of treatment. Macroscopic and densitometrical analysis revealed that flow distribution was most homogeneous in the dialyzer with a new bundle configuration. Significantly increased urea clearances (p

Original languageEnglish
Pages (from-to)380-388
Number of pages9
JournalHemodialysis International
Volume10
Issue number4
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Blood flow distribution
  • Dialysate flow distribution
  • Fiber packing density
  • Hemodialyzer configuration

ASJC Scopus subject areas

  • Hematology

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