Flower cells of tropical descent: a challenging case of adult T-cell leukemia/lymphoma

Giovanni Martino, Magda Zanelli, Andrea Marra, Martina Quintini, Maurizio Zizzo, Stefano Ascani, Maria Paola Martelli, Brunangelo Falini

Research output: Contribution to journalArticle

Abstract

Background: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive disease associated with human T-lymphotropic virus type 1 infection, with a very high prevalence in tropical areas but exceptionally rare in Europe and Western countries. Case presentation: We describe a challenging case of ATLL in a young male patient with Brazilian origin and adopted as a child by an Italian family, presenting to our clinic with atypical T-lymphocytosis and life-threatening lung infections. Conclusions: Diagnosis of ATLL outside of endemic areas can be difficult, requiring a high index of clinical suspicion with careful evaluation of the patient’s clinical history. Prognosis is affected by disease stage at presentation and degree of immunosuppression. Few effective treatments are available, although new molecular insights have highlighted the role of host immune response and immune checkpoint blockade inhibitors, given the overexpression of PD-L1 on lymphoma cells and on microenvironment cells.

Original languageEnglish
Pages (from-to)NP38-NP42
Number of pages5
JournalTumori
Volume105
Issue number6
DOIs
Publication statusPublished - Dec 1 2019

Keywords

  • Adult T-cell leukemia
  • HTLV-1
  • immunosurveillance
  • leukemia
  • PD-L1
  • T-cell lymphoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Martino, G., Zanelli, M., Marra, A., Quintini, M., Zizzo, M., Ascani, S., Martelli, M. P., & Falini, B. (2019). Flower cells of tropical descent: a challenging case of adult T-cell leukemia/lymphoma. Tumori, 105(6), NP38-NP42. https://doi.org/10.1177/0300891619847756