Flower cells of tropical descent: a challenging case of adult T-cell leukemia/lymphoma

Giovanni Martino, Magda Zanelli, Andrea Marra, Martina Quintini, Maurizio Zizzo, Stefano Ascani, Maria Paola Martelli, Brunangelo Falini

Research output: Contribution to journalArticle

Abstract

Background: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive disease associated with human T-lymphotropic virus type 1 infection, with a very high prevalence in tropical areas but exceptionally rare in Europe and Western countries. Case presentation: We describe a challenging case of ATLL in a young male patient with Brazilian origin and adopted as a child by an Italian family, presenting to our clinic with atypical T-lymphocytosis and life-threatening lung infections. Conclusions: Diagnosis of ATLL outside of endemic areas can be difficult, requiring a high index of clinical suspicion with careful evaluation of the patient’s clinical history. Prognosis is affected by disease stage at presentation and degree of immunosuppression. Few effective treatments are available, although new molecular insights have highlighted the role of host immune response and immune checkpoint blockade inhibitors, given the overexpression of PD-L1 on lymphoma cells and on microenvironment cells.

Original languageEnglish
JournalTumori
DOIs
Publication statusAccepted/In press - Jan 1 2019

Fingerprint

Adult T Cell Leukemia Lymphoma
Cellular Microenvironment
Lymphocytosis
Human T-lymphotropic virus 1
Virus Diseases
Immunosuppression
Lymphoma
Lung
Infection
Therapeutics

Keywords

  • Adult T-cell leukemia
  • HTLV-1
  • immunosurveillance
  • leukemia
  • PD-L1
  • T-cell lymphoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Martino, G., Zanelli, M., Marra, A., Quintini, M., Zizzo, M., Ascani, S., ... Falini, B. (Accepted/In press). Flower cells of tropical descent: a challenging case of adult T-cell leukemia/lymphoma. Tumori. https://doi.org/10.1177/0300891619847756

Flower cells of tropical descent : a challenging case of adult T-cell leukemia/lymphoma. / Martino, Giovanni; Zanelli, Magda; Marra, Andrea; Quintini, Martina; Zizzo, Maurizio; Ascani, Stefano; Martelli, Maria Paola; Falini, Brunangelo.

In: Tumori, 01.01.2019.

Research output: Contribution to journalArticle

Martino, Giovanni ; Zanelli, Magda ; Marra, Andrea ; Quintini, Martina ; Zizzo, Maurizio ; Ascani, Stefano ; Martelli, Maria Paola ; Falini, Brunangelo. / Flower cells of tropical descent : a challenging case of adult T-cell leukemia/lymphoma. In: Tumori. 2019.
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