FLT3 inhibition as a targeted therapy for acute myeloid leukemia

Miguel Sanz, Alan Burnett, Francesco Lo-Coco, Bob Lowenoerg

Research output: Contribution to journalArticlepeer-review

Abstract

The management of acute myeloid leukemia (AML) presents significant challenges, and there remains a need for new therapies with greater efficacy and better tolerability than existing treatments. An improved understanding of the genetic and molecular changes underlying AML can help both to guide treatment strategies and to predict clinical outcomes, thereby enabling more precise decision-making regarding the optimal treatment strategy for individual patients. Recent findings: The tyrosine kinase receptor FLT3 plays an important role in the survival and proliferation of blasts, and approximately 25% of patients with AML have mutations in the FLT3 gene. This protein is therefore an obvious therapeutic target in AML Amongst recently developed tyrosine kinase inhibitors of FLT3, lestaurtinib and midostaurin are two orally bioavailable agents that have shown encouraging activity, both preclinical and in relapsed AML, and are now in phase III clinical trials. These agents are also being tested in combination with conventional chemotherapy. Summary Oral FLT3 inhibitors offer a hope of improved treatment outcomes for patients with relapsed and newly diagnosed AML.

Original languageEnglish
Pages (from-to)594-600
Number of pages7
JournalCurrent Opinion in Oncology
Volume21
Issue number6
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Acute myeloid leukaemia
  • FLT3
  • Tyrosine kinase

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'FLT3 inhibition as a targeted therapy for acute myeloid leukemia'. Together they form a unique fingerprint.

Cite this