FLT3 internal tandem duplication in childhood acute myeloid leukaemia: Association with hyperleucocytosis in acute promyelocytic leukaemia

Paolo Arrigoni, Chiara Beretta, Daniela Silvestri, Vincenzo Rossi, Carmelo Rizzari, Maria Grazia Valsecchi, Giovanni Cazzaniga, Andrea Biondi

Research output: Contribution to journalArticle

Abstract

We evaluated the incidence of FLT3/internal tandem duplication (ITD) mutation in childhood acute myeloid leukaemia (AML) diagnosed over 15 years. FLT3/ITD was found in 10 of 45 (22.2%) non-acute promyelocytic leukaemia (non-APL) patients. The 5-year event-free survival of non-APL patients was higher in FLT3/ITD-negative versus -positive patients (48.9%, SE 8.9, vs 20.0%, SE 16.1, P = 0.03). In childhood APL, FLT3/ITD incidence was higher than in non-APL, although not statistically significant (10 out of 29 patients, 34.5%, P = 0.29). In APL patients, FLT3/ITD was strongly correlated to a higher white blood cell count at diagnosis and the M3 French-American-British subtype.

Original languageEnglish
Pages (from-to)89-92
Number of pages4
JournalBritish Journal of Haematology
Volume120
Issue number1
DOIs
Publication statusPublished - 2003

Keywords

  • Childhood AML
  • Childhood APL
  • FLT3/ITD
  • M3 variant

ASJC Scopus subject areas

  • Hematology

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