Fluconazole and itraconazole vs amphotericin B: In vitro comparative evaluation of the minimal inhibitory concentration (MIC) against isolated yeasts from HIV positive patients with oropharingeal candidiasis

M. Perduca, E. Marangoni, L. Sacco, E. Romero, G. Filice

Research output: Contribution to journalArticlepeer-review

Abstract

A broth macrodilution technique, performed by following the recommendations provided by the National Committee for Clinical Laboratory Standards, was applied to study the in vitro activity of amphotericin B, fluconazole and itraconazole against 204 fungal strains belonging to 16 different species of Candida isolates from the oral cavity of patients infected with human immunodeficiency virus. The in vitro data show an average MIC for amphotericin B (MIC 0.05 μg/ml) lower than fluconazole (MIC 2.06 μg/ml) and itraconazole (MIC 1.75 μg/ml), suggesting that amphotericin B remains one of the most effective antifungal drugs; itraconazole activity is slightly higher than fluconazole. We report amphotericin B MICs high values for one strain of C. krusei (100 μg/ml), C. kefyr (25 μg/ml), C. sake (12.5 μg/ml) and C. albicans (12.5 μg/ml).

Original languageEnglish
Pages (from-to)417-429
Number of pages13
JournalIgiene Moderna
Volume111
Issue number4
Publication statusPublished - 1999

Keywords

  • Amphotericin B
  • Broth macrodilution NCCLS method
  • Flucanazole
  • Itraconazole

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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