Fluconazole in the treatment of candidiasis in immunocompromised children

C. Viscoli, E. Castagnola, F. Fioredda, B. Ciravegna, G. Barigione, A. Terragna

Research output: Contribution to journalArticlepeer-review

Abstract

Fluconazole, a new triazole derivative, was evaluated in a pilot study of 34 episodes of candidiasis in 24 children. All the patients had predisposing conditions, such as human immunodeficiency virus infection, cancer, organ or bone marrow transplantation, neonatal age and malnutrition, and obstructive uropathy. The drug was administered at 6 mg/kg (body weight) once daily either orally or intravenously. Two patients with fungemia due to Candidaparapsilosis required an increased dosage of 12 mg/kg. Clinical and microbiological success was achieved in 30 of 34 cases (88%). Drug-related transaminase increases were observed in two cases (6%). Fluconazole may represent an effective alternative to amphotericin B in the treatment of candidiasis in children. Comparative trials are necessary to assess optimal dosages and efficacy.

Original languageEnglish
Pages (from-to)365-367
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume35
Issue number2
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Pharmacology (medical)

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