Abstract
We report the serum levels of soluble interleukin 2 receptor (sIL2R), β2-microglobulin (β2-M) and interferon-γ (IFN-γ) in patients undergoing adoptive immunotherapy with rIL 2 and lymphocyte-activated killer (LAK) cells. Our results indicate that rIL2 induced a marked increase of the serum concentration of these markers, although this increase varied considerably for different individuals. Parallel studies with the same patients also showed a marked rise in the number of IL 2R+ lymphocytes: the IL2Rs expressed on these cells were mainly of the 'low affinity' type. We suggest that evaluation of these markers may allow the monitoring of immune system activation induced by rIL2 in patients undergoing adoptive rIL2 and LAK cell immunotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 305-315 |
| Number of pages | 11 |
| Journal | Immunobiology |
| Volume | 178 |
| Issue number | 4-5 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Immunology
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Fluctuations of plasma β2-microglobulin, soluble interleukin 2 receptor and interferon-gamma concentrations after adoptive immunotherapy with high-dose interleukin 2 and lymphokine-activated killer cells. / Giannella, G.; Pelosi-Testa, E.; Carlini, P.; Habetswallner, D.; Montesoro, E.; Camagna, A.; Calzini, V.; Ruggeri, E. M.; Arena, M. G.; Masciulli, R.; Bulgarini, D.; Samoggia, P.; Di Folco, S.; Petrillo, G.; Sofra, M. G.; Boccoli, G.; Mastroberardino, G.; Calabresi, F.; Testa, U.; Peschle, C.
In: Immunobiology, Vol. 178, No. 4-5, 1989, p. 305-315.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fluctuations of plasma β2-microglobulin, soluble interleukin 2 receptor and interferon-gamma concentrations after adoptive immunotherapy with high-dose interleukin 2 and lymphokine-activated killer cells
AU - Giannella, G.
AU - Pelosi-Testa, E.
AU - Carlini, P.
AU - Habetswallner, D.
AU - Montesoro, E.
AU - Camagna, A.
AU - Calzini, V.
AU - Ruggeri, E. M.
AU - Arena, M. G.
AU - Masciulli, R.
AU - Bulgarini, D.
AU - Samoggia, P.
AU - Di Folco, S.
AU - Petrillo, G.
AU - Sofra, M. G.
AU - Boccoli, G.
AU - Mastroberardino, G.
AU - Calabresi, F.
AU - Testa, U.
AU - Peschle, C.
PY - 1989
Y1 - 1989
N2 - We report the serum levels of soluble interleukin 2 receptor (sIL2R), β2-microglobulin (β2-M) and interferon-γ (IFN-γ) in patients undergoing adoptive immunotherapy with rIL 2 and lymphocyte-activated killer (LAK) cells. Our results indicate that rIL2 induced a marked increase of the serum concentration of these markers, although this increase varied considerably for different individuals. Parallel studies with the same patients also showed a marked rise in the number of IL 2R+ lymphocytes: the IL2Rs expressed on these cells were mainly of the 'low affinity' type. We suggest that evaluation of these markers may allow the monitoring of immune system activation induced by rIL2 in patients undergoing adoptive rIL2 and LAK cell immunotherapy.
AB - We report the serum levels of soluble interleukin 2 receptor (sIL2R), β2-microglobulin (β2-M) and interferon-γ (IFN-γ) in patients undergoing adoptive immunotherapy with rIL 2 and lymphocyte-activated killer (LAK) cells. Our results indicate that rIL2 induced a marked increase of the serum concentration of these markers, although this increase varied considerably for different individuals. Parallel studies with the same patients also showed a marked rise in the number of IL 2R+ lymphocytes: the IL2Rs expressed on these cells were mainly of the 'low affinity' type. We suggest that evaluation of these markers may allow the monitoring of immune system activation induced by rIL2 in patients undergoing adoptive rIL2 and LAK cell immunotherapy.
UR - http://www.scopus.com/inward/record.url?scp=0024512094&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024512094&partnerID=8YFLogxK
M3 - Article
C2 - 2497064
AN - SCOPUS:0024512094
VL - 178
SP - 305
EP - 315
JO - Immunobiology
JF - Immunobiology
SN - 0171-2985
IS - 4-5
ER -