Fluctuations of plasma β2-microglobulin, soluble interleukin 2 receptor and interferon-gamma concentrations after adoptive immunotherapy with high-dose interleukin 2 and lymphokine-activated killer cells

G. Giannella, E. Pelosi-Testa, P. Carlini, D. Habetswallner, E. Montesoro, A. Camagna, V. Calzini, E. M. Ruggeri, M. G. Arena, R. Masciulli, D. Bulgarini, P. Samoggia, S. Di Folco, G. Petrillo, M. G. Sofra, G. Boccoli, G. Mastroberardino, F. Calabresi, U. Testa, C. Peschle

Research output: Contribution to journalArticle

Abstract

We report the serum levels of soluble interleukin 2 receptor (sIL2R), β2-microglobulin (β2-M) and interferon-γ (IFN-γ) in patients undergoing adoptive immunotherapy with rIL 2 and lymphocyte-activated killer (LAK) cells. Our results indicate that rIL2 induced a marked increase of the serum concentration of these markers, although this increase varied considerably for different individuals. Parallel studies with the same patients also showed a marked rise in the number of IL 2R+ lymphocytes: the IL2Rs expressed on these cells were mainly of the 'low affinity' type. We suggest that evaluation of these markers may allow the monitoring of immune system activation induced by rIL2 in patients undergoing adoptive rIL2 and LAK cell immunotherapy.

Original languageEnglish
Pages (from-to)305-315
Number of pages11
JournalImmunobiology
Volume178
Issue number4-5
Publication statusPublished - 1989

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Adoptive Immunotherapy
Lymphokine-Activated Killer Cells
Interleukin-2 Receptors
Cytokine-Induced Killer Cells
Interferon-gamma
Interleukin-2
Immunotherapy
Interferons
Immune System
Biomarkers
Lymphocytes
Serum

ASJC Scopus subject areas

  • Immunology

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Fluctuations of plasma β2-microglobulin, soluble interleukin 2 receptor and interferon-gamma concentrations after adoptive immunotherapy with high-dose interleukin 2 and lymphokine-activated killer cells. / Giannella, G.; Pelosi-Testa, E.; Carlini, P.; Habetswallner, D.; Montesoro, E.; Camagna, A.; Calzini, V.; Ruggeri, E. M.; Arena, M. G.; Masciulli, R.; Bulgarini, D.; Samoggia, P.; Di Folco, S.; Petrillo, G.; Sofra, M. G.; Boccoli, G.; Mastroberardino, G.; Calabresi, F.; Testa, U.; Peschle, C.

In: Immunobiology, Vol. 178, No. 4-5, 1989, p. 305-315.

Research output: Contribution to journalArticle

Giannella, G, Pelosi-Testa, E, Carlini, P, Habetswallner, D, Montesoro, E, Camagna, A, Calzini, V, Ruggeri, EM, Arena, MG, Masciulli, R, Bulgarini, D, Samoggia, P, Di Folco, S, Petrillo, G, Sofra, MG, Boccoli, G, Mastroberardino, G, Calabresi, F, Testa, U & Peschle, C 1989, 'Fluctuations of plasma β2-microglobulin, soluble interleukin 2 receptor and interferon-gamma concentrations after adoptive immunotherapy with high-dose interleukin 2 and lymphokine-activated killer cells', Immunobiology, vol. 178, no. 4-5, pp. 305-315.
Giannella, G. ; Pelosi-Testa, E. ; Carlini, P. ; Habetswallner, D. ; Montesoro, E. ; Camagna, A. ; Calzini, V. ; Ruggeri, E. M. ; Arena, M. G. ; Masciulli, R. ; Bulgarini, D. ; Samoggia, P. ; Di Folco, S. ; Petrillo, G. ; Sofra, M. G. ; Boccoli, G. ; Mastroberardino, G. ; Calabresi, F. ; Testa, U. ; Peschle, C. / Fluctuations of plasma β2-microglobulin, soluble interleukin 2 receptor and interferon-gamma concentrations after adoptive immunotherapy with high-dose interleukin 2 and lymphokine-activated killer cells. In: Immunobiology. 1989 ; Vol. 178, No. 4-5. pp. 305-315.
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AU - Pelosi-Testa, E.

AU - Carlini, P.

AU - Habetswallner, D.

AU - Montesoro, E.

AU - Camagna, A.

AU - Calzini, V.

AU - Ruggeri, E. M.

AU - Arena, M. G.

AU - Masciulli, R.

AU - Bulgarini, D.

AU - Samoggia, P.

AU - Di Folco, S.

AU - Petrillo, G.

AU - Sofra, M. G.

AU - Boccoli, G.

AU - Mastroberardino, G.

AU - Calabresi, F.

AU - Testa, U.

AU - Peschle, C.

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