Fludarabine-Containing Chemotherapy as Frontline Treatment of Nongastrointestinal Mucosa-Associated Lymphoid Tissue Lymphoma

Pier Luigi Zinzani, Vittorio Stefoni, Gerardo Musuraca, Monica Tani, Lapo Alinari, Annalisa Gabriele, Enrica Marchi, Stefano Pileri, Michele Baccarani

Research output: Contribution to journalArticlepeer-review


BACKGROUND. Mucosa-associated lymphoid tissue (MALT) lymphoma is a specific clinicopathologic entity with gastric and nongastrointestinal site involvement. The authors reported the clinical outcome of patients with Stage IE nongastrointestinal MALT lymphoma treated with a frontline fludarabine-containing regimen or with a regimen containing cyclophosphamide, vincristine, and prednisone (CVP). METHODS. Between 1998 and 2001, 31 patients with Stage IE disease were referred to the Seràgnoli Institute of Hematology and Medical Oncology at the University of Bologna (Bologna, Italy). Presenting sites included periorbital soft tissue (n = 8), lung (n = 5), skin (n = 5), salivary glands (n = 5), lacrimal glands (n = 5), and thyroid (n = 3). Twenty patients were treated with fludarabine and mitoxantrone (FM), and 11 were treated with the CVP regimen. The median follow-up was 3 years. RESULTS. All patients achieved complete responses (CR). Four patients, all treated with CVP, experienced disease recurrence and then achieved a second CR after FM salvage treatment. No tumor recurrence was observed in patients with thyroid, lacrimal gland, or pulmonary lymphoma. The projected 5-year overall survival and disease-free survival rates were 100% and 85%, respectively. CONCLUSIONS. The fludarabine-containing FM regimen provided a relatively effective frontline (or salvage) treatment option for patients with nongastrointestinal Stage IE MALT lymphoma and probably was superior to CVP in terms of efficacy.

Original languageEnglish
Pages (from-to)2190-2194
Number of pages5
Issue number10
Publication statusPublished - May 15 2004


  • Disease-free survival
  • Fludarabine-containing regimen
  • Mucosa-associated lymphoid tissue lymphoma
  • Nongastrointestinal sites

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


Dive into the research topics of 'Fludarabine-Containing Chemotherapy as Frontline Treatment of Nongastrointestinal Mucosa-Associated Lymphoid Tissue Lymphoma'. Together they form a unique fingerprint.

Cite this