'Fludarabine containing-regimens may adversely affect peripheral blood stem cell collection in low-grade non Hodgkin lymphoma patients'

Daniele Laszlo, Piero Galieni, Donatella Raspadori, Giulia Scalia, Catia Bigazzi, Monica Bocchia, Alessandro Bucalossi, Giuseppe Marotta, Monica Tozzi, Francesco Lauria

Research output: Contribution to journalArticlepeer-review

Abstract

Fludarabine (FLUDA) based chemotherapy has shown promise in both initial and salvage treatment of low-grade non Hodgkin's lymphomas (LG-NHL). Recently, more aggressive therapies followed by autologous hemopoietic progenitor cell rescue, have also been successfully employed in these patients. However, this procedure, due to several factors including previous therapeutic regimens, is often limited by an inadequate collection of peripheral blood stem cell (PBSC). At present, very little data is available on the effect of FLUDA containing regimens in PBSC collection. We report our preliminary experience showing a possible correlation between FLUDA based chemotherapy regimens employed before mobilization and inability to collect an adequate number of blood derived hematopoietic progenitors for autologous PBSC transplantation in LG-NHL patients.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalLeukemia and Lymphoma
Volume37
Issue number1-2
Publication statusPublished - 2000

Keywords

  • Fludarabine
  • LG-NHL
  • PBSC collection

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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