'Fludarabine containing-regimens may adversely affect peripheral blood stem cell collection in low-grade non Hodgkin lymphoma patients'

Daniele Laszlo, Piero Galieni, Donatella Raspadori, Giulia Scalia, Catia Bigazzi, Monica Bocchia, Alessandro Bucalossi, Giuseppe Marotta, Monica Tozzi, Francesco Lauria

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Fludarabine (FLUDA) based chemotherapy has shown promise in both initial and salvage treatment of low-grade non Hodgkin's lymphomas (LG-NHL). Recently, more aggressive therapies followed by autologous hemopoietic progenitor cell rescue, have also been successfully employed in these patients. However, this procedure, due to several factors including previous therapeutic regimens, is often limited by an inadequate collection of peripheral blood stem cell (PBSC). At present, very little data is available on the effect of FLUDA containing regimens in PBSC collection. We report our preliminary experience showing a possible correlation between FLUDA based chemotherapy regimens employed before mobilization and inability to collect an adequate number of blood derived hematopoietic progenitors for autologous PBSC transplantation in LG-NHL patients.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalLeukemia and Lymphoma
Volume37
Issue number1-2
Publication statusPublished - 2000

Fingerprint

Non-Hodgkin's Lymphoma
Peripheral Blood Stem Cell Transplantation
Drug Therapy
Salvage Therapy
Stem Cells
Peripheral Blood Stem Cells
fludarabine
Therapeutics

Keywords

  • Fludarabine
  • LG-NHL
  • PBSC collection

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Laszlo, D., Galieni, P., Raspadori, D., Scalia, G., Bigazzi, C., Bocchia, M., ... Lauria, F. (2000). 'Fludarabine containing-regimens may adversely affect peripheral blood stem cell collection in low-grade non Hodgkin lymphoma patients'. Leukemia and Lymphoma, 37(1-2), 157-161.

'Fludarabine containing-regimens may adversely affect peripheral blood stem cell collection in low-grade non Hodgkin lymphoma patients'. / Laszlo, Daniele; Galieni, Piero; Raspadori, Donatella; Scalia, Giulia; Bigazzi, Catia; Bocchia, Monica; Bucalossi, Alessandro; Marotta, Giuseppe; Tozzi, Monica; Lauria, Francesco.

In: Leukemia and Lymphoma, Vol. 37, No. 1-2, 2000, p. 157-161.

Research output: Contribution to journalArticle

Laszlo, D, Galieni, P, Raspadori, D, Scalia, G, Bigazzi, C, Bocchia, M, Bucalossi, A, Marotta, G, Tozzi, M & Lauria, F 2000, ''Fludarabine containing-regimens may adversely affect peripheral blood stem cell collection in low-grade non Hodgkin lymphoma patients'', Leukemia and Lymphoma, vol. 37, no. 1-2, pp. 157-161.
Laszlo, Daniele ; Galieni, Piero ; Raspadori, Donatella ; Scalia, Giulia ; Bigazzi, Catia ; Bocchia, Monica ; Bucalossi, Alessandro ; Marotta, Giuseppe ; Tozzi, Monica ; Lauria, Francesco. / 'Fludarabine containing-regimens may adversely affect peripheral blood stem cell collection in low-grade non Hodgkin lymphoma patients'. In: Leukemia and Lymphoma. 2000 ; Vol. 37, No. 1-2. pp. 157-161.
@article{a80c3f0d25e745fda9787e530093749e,
title = "'Fludarabine containing-regimens may adversely affect peripheral blood stem cell collection in low-grade non Hodgkin lymphoma patients'",
abstract = "Fludarabine (FLUDA) based chemotherapy has shown promise in both initial and salvage treatment of low-grade non Hodgkin's lymphomas (LG-NHL). Recently, more aggressive therapies followed by autologous hemopoietic progenitor cell rescue, have also been successfully employed in these patients. However, this procedure, due to several factors including previous therapeutic regimens, is often limited by an inadequate collection of peripheral blood stem cell (PBSC). At present, very little data is available on the effect of FLUDA containing regimens in PBSC collection. We report our preliminary experience showing a possible correlation between FLUDA based chemotherapy regimens employed before mobilization and inability to collect an adequate number of blood derived hematopoietic progenitors for autologous PBSC transplantation in LG-NHL patients.",
keywords = "Fludarabine, LG-NHL, PBSC collection",
author = "Daniele Laszlo and Piero Galieni and Donatella Raspadori and Giulia Scalia and Catia Bigazzi and Monica Bocchia and Alessandro Bucalossi and Giuseppe Marotta and Monica Tozzi and Francesco Lauria",
year = "2000",
language = "English",
volume = "37",
pages = "157--161",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Taylor and Francis Ltd.",
number = "1-2",

}

TY - JOUR

T1 - 'Fludarabine containing-regimens may adversely affect peripheral blood stem cell collection in low-grade non Hodgkin lymphoma patients'

AU - Laszlo, Daniele

AU - Galieni, Piero

AU - Raspadori, Donatella

AU - Scalia, Giulia

AU - Bigazzi, Catia

AU - Bocchia, Monica

AU - Bucalossi, Alessandro

AU - Marotta, Giuseppe

AU - Tozzi, Monica

AU - Lauria, Francesco

PY - 2000

Y1 - 2000

N2 - Fludarabine (FLUDA) based chemotherapy has shown promise in both initial and salvage treatment of low-grade non Hodgkin's lymphomas (LG-NHL). Recently, more aggressive therapies followed by autologous hemopoietic progenitor cell rescue, have also been successfully employed in these patients. However, this procedure, due to several factors including previous therapeutic regimens, is often limited by an inadequate collection of peripheral blood stem cell (PBSC). At present, very little data is available on the effect of FLUDA containing regimens in PBSC collection. We report our preliminary experience showing a possible correlation between FLUDA based chemotherapy regimens employed before mobilization and inability to collect an adequate number of blood derived hematopoietic progenitors for autologous PBSC transplantation in LG-NHL patients.

AB - Fludarabine (FLUDA) based chemotherapy has shown promise in both initial and salvage treatment of low-grade non Hodgkin's lymphomas (LG-NHL). Recently, more aggressive therapies followed by autologous hemopoietic progenitor cell rescue, have also been successfully employed in these patients. However, this procedure, due to several factors including previous therapeutic regimens, is often limited by an inadequate collection of peripheral blood stem cell (PBSC). At present, very little data is available on the effect of FLUDA containing regimens in PBSC collection. We report our preliminary experience showing a possible correlation between FLUDA based chemotherapy regimens employed before mobilization and inability to collect an adequate number of blood derived hematopoietic progenitors for autologous PBSC transplantation in LG-NHL patients.

KW - Fludarabine

KW - LG-NHL

KW - PBSC collection

UR - http://www.scopus.com/inward/record.url?scp=17344388562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17344388562&partnerID=8YFLogxK

M3 - Article

VL - 37

SP - 157

EP - 161

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 1-2

ER -