Abstract
Fludarabine (FLUDA) based chemotherapy has shown promise in both initial and salvage treatment of low-grade non Hodgkin's lymphomas (LG-NHL). Recently, more aggressive therapies followed by autologous hemopoietic progenitor cell rescue, have also been successfully employed in these patients. However, this procedure, due to several factors including previous therapeutic regimens, is often limited by an inadequate collection of peripheral blood stem cell (PBSC). At present, very little data is available on the effect of FLUDA containing regimens in PBSC collection. We report our preliminary experience showing a possible correlation between FLUDA based chemotherapy regimens employed before mobilization and inability to collect an adequate number of blood derived hematopoietic progenitors for autologous PBSC transplantation in LG-NHL patients.
| Original language | English |
|---|---|
| Pages (from-to) | 157-161 |
| Number of pages | 5 |
| Journal | Leukemia and Lymphoma |
| Volume | 37 |
| Issue number | 1-2 |
| Publication status | Published - 2000 |
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Keywords
- Fludarabine
- LG-NHL
- PBSC collection
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
Cite this
'Fludarabine containing-regimens may adversely affect peripheral blood stem cell collection in low-grade non Hodgkin lymphoma patients'. / Laszlo, Daniele; Galieni, Piero; Raspadori, Donatella; Scalia, Giulia; Bigazzi, Catia; Bocchia, Monica; Bucalossi, Alessandro; Marotta, Giuseppe; Tozzi, Monica; Lauria, Francesco.
In: Leukemia and Lymphoma, Vol. 37, No. 1-2, 2000, p. 157-161.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 'Fludarabine containing-regimens may adversely affect peripheral blood stem cell collection in low-grade non Hodgkin lymphoma patients'
AU - Laszlo, Daniele
AU - Galieni, Piero
AU - Raspadori, Donatella
AU - Scalia, Giulia
AU - Bigazzi, Catia
AU - Bocchia, Monica
AU - Bucalossi, Alessandro
AU - Marotta, Giuseppe
AU - Tozzi, Monica
AU - Lauria, Francesco
PY - 2000
Y1 - 2000
N2 - Fludarabine (FLUDA) based chemotherapy has shown promise in both initial and salvage treatment of low-grade non Hodgkin's lymphomas (LG-NHL). Recently, more aggressive therapies followed by autologous hemopoietic progenitor cell rescue, have also been successfully employed in these patients. However, this procedure, due to several factors including previous therapeutic regimens, is often limited by an inadequate collection of peripheral blood stem cell (PBSC). At present, very little data is available on the effect of FLUDA containing regimens in PBSC collection. We report our preliminary experience showing a possible correlation between FLUDA based chemotherapy regimens employed before mobilization and inability to collect an adequate number of blood derived hematopoietic progenitors for autologous PBSC transplantation in LG-NHL patients.
AB - Fludarabine (FLUDA) based chemotherapy has shown promise in both initial and salvage treatment of low-grade non Hodgkin's lymphomas (LG-NHL). Recently, more aggressive therapies followed by autologous hemopoietic progenitor cell rescue, have also been successfully employed in these patients. However, this procedure, due to several factors including previous therapeutic regimens, is often limited by an inadequate collection of peripheral blood stem cell (PBSC). At present, very little data is available on the effect of FLUDA containing regimens in PBSC collection. We report our preliminary experience showing a possible correlation between FLUDA based chemotherapy regimens employed before mobilization and inability to collect an adequate number of blood derived hematopoietic progenitors for autologous PBSC transplantation in LG-NHL patients.
KW - Fludarabine
KW - LG-NHL
KW - PBSC collection
UR - http://www.scopus.com/inward/record.url?scp=17344388562&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17344388562&partnerID=8YFLogxK
M3 - Article
VL - 37
SP - 157
EP - 161
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 1-2
ER -