Fludarabine, cyclophosphamide and anti-thymocyte globulin for alternative donor transplants in acquired severe aplastic anemia: A report from the EBMT-SAA Working Party

Andrea Bacigalupo, F. Locatelli, E. Lanino, J. Marsh, G. Socié, S. Maury, A. Prete, A. Locasciulli, S. Cesaro, J. Passweg

Research output: Contribution to journalArticlepeer-review

Abstract

We have developed a reduced-intensity conditioning regimen for patients with severe aplastic anemia (SAA) undergoing alternative donor transplants, which includes fludarabine (120mg/m 2), cyclophosphamide (1200mg/m 2) and antithymocyte globulin (7.5mg/kg). Graft-versus-host disease (GvHD) prophylaxis consisted of cyclosporine and methotrexate. We have enrolled 38 SAA patients in this trial: median age of 14 (3-37) years, transplanted from unrelated (n=33) or family mismatched (n=5) donors, with unmanipulated marrow (n=36) or peripheral blood (n=2). Seven patients (18%) had evidence of graft failure, 11% developed grade II-III acute GvHD and 27% developed chronic GvHD. The actuarial 2-year survival is 73% with a median follow-up of 621 days. Younger patients (≤14 years) had a lower risk of rejection (5%) and improved actuarial survival (84%). Causes of death were infections (n=3), graft failure (n=2), Epstein-Barr virus lymphoma (n=2) and hemorrhage (n=2). In conclusion, the actuarial 2-year survival is encouraging in young SAA patients receiving a radiation-free conditioning regimen. The significant risk of graft failure in patients 15 years or older may require modification of the conditioning regimen in adults.

Original languageEnglish
Pages (from-to)947-950
Number of pages4
JournalBone Marrow Transplantation
Volume36
Issue number11
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Anti-thymocyte globulin
  • Aplastic anemia
  • Reduced-intensity conditioning

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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