Fludarabine plus alemtuzumab (FA) front-line treatment in young patients with chronic lymphocytic leukemia (CLL) and an adverse biologic profile

Francesca R. Mauro; Stefano Molica; Luca Laurenti; Agostino Cortelezzi; Angelo M. Carella; Francesco Zaja; Annalisa Chiarenza; Francesco Angrilli; Francesco Nobile; Roberto Marasca; Caterina Musolino; Maura Brugiatelli; Alfonso Piciocchi; Marco Vignetti; Paola Fazi; Giuseppe Gentile; Maria S. De Propris; Irene Della Starza; Marilisa Marinelli; Sabina Chiaretti; Ilaria Del Giudice; Mauro Nanni; Francesco Albano; Antonio Cuneo; Anna Guarini; Robin Foà

doi:10.1016/j.leukres.2013.11.009

Fludarabine plus alemtuzumab (FA) front-line treatment in young patients with chronic lymphocytic leukemia (CLL) and an adverse biologic profile

Francesca R. Mauro, Stefano Molica, Luca Laurenti, Agostino Cortelezzi, Angelo M. Carella, Francesco Zaja, Annalisa Chiarenza, Francesco Angrilli, Francesco Nobile, Roberto Marasca, Caterina Musolino, Maura Brugiatelli, Alfonso Piciocchi, Marco Vignetti, Paola Fazi, Giuseppe Gentile, Maria S. De Propris, Irene Della Starza, Marilisa Marinelli, Sabina ChiarettiIlaria Del Giudice, Mauro Nanni, Francesco Albano, Antonio Cuneo, Anna Guarini, Robin Foà

Research output: Contribution to journal › Article

Abstract

In 45, ≤60 years old patients with CLL and an adverse biologic profile, a front-line treatment with Fludarabine and Campath (Alemtuzumab^®) was given. The overall response rate was 75.5%, the complete response rate (CR) 24.4% with the lowest CR rates, 16.7% and 8.3%, in 11q and 17p deleted cases. The 3-year progression-free survival (PFS) and overall survival were 42.5% and 79.9%, respectively. PFS was significantly influenced by CLL duration, beta2-microglobulin, and improved by post-remissional stem cell transplantation. Front-line fludarabine and alemtuzumab showed a manageable safety profile and evidence of a benefit in a small series of CLL patients with adverse biologic features.

Original language	English
Pages (from-to)	198-203
Number of pages	6
Journal	Leukemia Research
Volume	38
Issue number	2
DOIs	https://doi.org/10.1016/j.leukres.2013.11.009
Publication status	Published - Feb 2014

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Keywords

Alemtuzumab
Biology
Chronic lymphocytic leukemia
CLL
Fludarabine
Young

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology
Medicine(all)

Cite this

Mauro, F. R., Molica, S., Laurenti, L., Cortelezzi, A., Carella, A. M., Zaja, F., Chiarenza, A., Angrilli, F., Nobile, F., Marasca, R., Musolino, C., Brugiatelli, M., Piciocchi, A., Vignetti, M., Fazi, P., Gentile, G., De Propris, M. S., Starza, I. D., Marinelli, M., ... Foà, R. (2014). Fludarabine plus alemtuzumab (FA) front-line treatment in young patients with chronic lymphocytic leukemia (CLL) and an adverse biologic profile. Leukemia Research, 38(2), 198-203. https://doi.org/10.1016/j.leukres.2013.11.009

Fludarabine plus alemtuzumab (FA) front-line treatment in young patients with chronic lymphocytic leukemia (CLL) and an adverse biologic profile. / Mauro, Francesca R.; Molica, Stefano; Laurenti, Luca; Cortelezzi, Agostino ; Carella, Angelo M.; Zaja, Francesco; Chiarenza, Annalisa; Angrilli, Francesco; Nobile, Francesco; Marasca, Roberto; Musolino, Caterina; Brugiatelli, Maura; Piciocchi, Alfonso; Vignetti, Marco; Fazi, Paola; Gentile, Giuseppe; De Propris, Maria S.; Starza, Irene Della; Marinelli, Marilisa; Chiaretti, Sabina; Del Giudice, Ilaria; Nanni, Mauro; Albano, Francesco; Cuneo, Antonio; Guarini, Anna; Foà, Robin.

In: Leukemia Research, Vol. 38, No. 2, 02.2014, p. 198-203.

Research output: Contribution to journal › Article

Mauro, FR, Molica, S, Laurenti, L, Cortelezzi, A , Carella, AM, Zaja, F, Chiarenza, A, Angrilli, F, Nobile, F, Marasca, R, Musolino, C, Brugiatelli, M, Piciocchi, A, Vignetti, M, Fazi, P, Gentile, G, De Propris, MS, Starza, ID, Marinelli, M, Chiaretti, S, Del Giudice, I, Nanni, M, Albano, F, Cuneo, A, Guarini, A & Foà, R 2014, 'Fludarabine plus alemtuzumab (FA) front-line treatment in young patients with chronic lymphocytic leukemia (CLL) and an adverse biologic profile', Leukemia Research, vol. 38, no. 2, pp. 198-203. https://doi.org/10.1016/j.leukres.2013.11.009

Mauro, Francesca R. ; Molica, Stefano ; Laurenti, Luca ; Cortelezzi, Agostino ; Carella, Angelo M. ; Zaja, Francesco ; Chiarenza, Annalisa ; Angrilli, Francesco ; Nobile, Francesco ; Marasca, Roberto ; Musolino, Caterina ; Brugiatelli, Maura ; Piciocchi, Alfonso ; Vignetti, Marco ; Fazi, Paola ; Gentile, Giuseppe ; De Propris, Maria S. ; Starza, Irene Della ; Marinelli, Marilisa ; Chiaretti, Sabina ; Del Giudice, Ilaria ; Nanni, Mauro ; Albano, Francesco ; Cuneo, Antonio ; Guarini, Anna ; Foà, Robin. / Fludarabine plus alemtuzumab (FA) front-line treatment in young patients with chronic lymphocytic leukemia (CLL) and an adverse biologic profile. In: Leukemia Research. 2014 ; Vol. 38, No. 2. pp. 198-203.

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10.1016/j.leukres.2013.11.009