Abstract
Sleep and waking have been traditionally considered global behavioural states regulated by subcortical neuromodulatory circuits in a top-down fashion. Over the last years, we have been experiencing a paradigm shift towards a view that both wake and sleep are in essence local processes. Here we review recent clinical and basic research works supporting this view by taking advantage of stereotactic electroencephalography (Stereo-EEG, SEEG) recordings performed in epileptic patients. Specifically, we will discuss a growing body of evidence showing how electrophysiological features of sleep and wakefulness are coexisting across diffuse brain areas in pathological and physiological sleep as well as during state transitions (sleep onset and awakenings). Finally, we will discuss their implication for sleep medicine to extent that, reconsidering the classical definition of wakefulness and sleep as separate and mutually exclusive states may offer new insight for the understanding of parasomnias and other dissociated states.
| Original language | English |
|---|---|
| Pages (from-to) | 169-177 |
| Number of pages | 9 |
| Journal | Archives Italiennes de Biologie |
| Volume | 152 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Dissociated states
- NREM parasomnias
- Stereo-EEG
- Wake-sleep transition
ASJC Scopus subject areas
- Medicine(all)
- Cell Biology
- Physiology
Cite this
Fluid boundaries between wake and sleep : Experimental evidence from Stereo-EEG recordings. / Sarasso, S.; Pigorini, A.; Proserpio, P.; Gibbs, S. A.; Massimini, M.; Nobili, Lino.
In: Archives Italiennes de Biologie, Vol. 152, No. 2-3, 2014, p. 169-177.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fluid boundaries between wake and sleep
T2 - Experimental evidence from Stereo-EEG recordings
AU - Sarasso, S.
AU - Pigorini, A.
AU - Proserpio, P.
AU - Gibbs, S. A.
AU - Massimini, M.
AU - Nobili, Lino
PY - 2014
Y1 - 2014
N2 - Sleep and waking have been traditionally considered global behavioural states regulated by subcortical neuromodulatory circuits in a top-down fashion. Over the last years, we have been experiencing a paradigm shift towards a view that both wake and sleep are in essence local processes. Here we review recent clinical and basic research works supporting this view by taking advantage of stereotactic electroencephalography (Stereo-EEG, SEEG) recordings performed in epileptic patients. Specifically, we will discuss a growing body of evidence showing how electrophysiological features of sleep and wakefulness are coexisting across diffuse brain areas in pathological and physiological sleep as well as during state transitions (sleep onset and awakenings). Finally, we will discuss their implication for sleep medicine to extent that, reconsidering the classical definition of wakefulness and sleep as separate and mutually exclusive states may offer new insight for the understanding of parasomnias and other dissociated states.
AB - Sleep and waking have been traditionally considered global behavioural states regulated by subcortical neuromodulatory circuits in a top-down fashion. Over the last years, we have been experiencing a paradigm shift towards a view that both wake and sleep are in essence local processes. Here we review recent clinical and basic research works supporting this view by taking advantage of stereotactic electroencephalography (Stereo-EEG, SEEG) recordings performed in epileptic patients. Specifically, we will discuss a growing body of evidence showing how electrophysiological features of sleep and wakefulness are coexisting across diffuse brain areas in pathological and physiological sleep as well as during state transitions (sleep onset and awakenings). Finally, we will discuss their implication for sleep medicine to extent that, reconsidering the classical definition of wakefulness and sleep as separate and mutually exclusive states may offer new insight for the understanding of parasomnias and other dissociated states.
KW - Dissociated states
KW - NREM parasomnias
KW - Stereo-EEG
KW - Wake-sleep transition
UR - http://www.scopus.com/inward/record.url?scp=84928196905&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928196905&partnerID=8YFLogxK
U2 - 10.12871/0002982920142311
DO - 10.12871/0002982920142311
M3 - Article
C2 - 25828688
AN - SCOPUS:84928196905
VL - 152
SP - 169
EP - 177
JO - Archives Italiennes de Biologie
JF - Archives Italiennes de Biologie
SN - 0003-9829
IS - 2-3
ER -