TY - JOUR
T1 - Fluid cartilage as new autologous biomaterial in the treatment of minor nose defects
T2 - Clinical and microscopic difference amongst diced, crushed, and fluid cartilage
AU - Trivisonno, Angelo
AU - Cohen, Steven R.
AU - Magalon, Guy
AU - Magalon, Jèrèmy
AU - Sterodimas, Aris
AU - Pascali, Michele
AU - Cervelli, Valerio
AU - Toietta, Gabriele
AU - Colaprietra, Alfredo
AU - Calcagni, Filippo
AU - Orlandi, Augusto
AU - Scioli, Maria Giovanni
AU - Gentile, Pietro
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Developing cartilage constructs with injectability, appropriate matrix composition, and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. Fourteen patients with minor contour deformity were treated with fluid cartilage filler gently injected as autologous fluid graft in deep planes of defect of the nose that were close to the bone or the cartilage. A computerized tomographic scan control was performed after 12 months. Pearson's Chi-square test was used to investigate differences in cartilage density between native and newly formed cartilages. The endpoints were the possibility of using fluid cartilage as filler with aesthetic and functional improvement and versatility. Patients were followed up for two years. The constructs of fluid cartilage graft that were injected in the deep plane resulted in a persistent cartilage tissue with appropriate morphology, adequate central nutritional perfusion without central necrosis or ossification, and further augmented nasal dorsum without obvious contraction and deformation. This report demonstrated that fluid cartilage grafts are useful for cartilage regeneration in patients with outcomes of rhinoplasty, internal nasal valve collapse, and minor congenital nose aesthetics deformity.
AB - Developing cartilage constructs with injectability, appropriate matrix composition, and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. Fourteen patients with minor contour deformity were treated with fluid cartilage filler gently injected as autologous fluid graft in deep planes of defect of the nose that were close to the bone or the cartilage. A computerized tomographic scan control was performed after 12 months. Pearson's Chi-square test was used to investigate differences in cartilage density between native and newly formed cartilages. The endpoints were the possibility of using fluid cartilage as filler with aesthetic and functional improvement and versatility. Patients were followed up for two years. The constructs of fluid cartilage graft that were injected in the deep plane resulted in a persistent cartilage tissue with appropriate morphology, adequate central nutritional perfusion without central necrosis or ossification, and further augmented nasal dorsum without obvious contraction and deformation. This report demonstrated that fluid cartilage grafts are useful for cartilage regeneration in patients with outcomes of rhinoplasty, internal nasal valve collapse, and minor congenital nose aesthetics deformity.
KW - Crushing cartilage
KW - Diced cartilage
KW - Fluid cartilage
KW - Minor nose defects
KW - Rhinoplasty
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U2 - 10.3390/ma12071062
DO - 10.3390/ma12071062
M3 - Article
AN - SCOPUS:85065649912
VL - 12
JO - Materials
JF - Materials
SN - 1996-1944
IS - 7
ER -