Fluid cartilage as new autologous biomaterial in the treatment of minor nose defects: Clinical and microscopic difference amongst diced, crushed, and fluid cartilage

Angelo Trivisonno, Steven R. Cohen, Guy Magalon, Jèrèmy Magalon, Aris Sterodimas, Michele Pascali, Valerio Cervelli, Gabriele Toietta, Alfredo Colaprietra, Filippo Calcagni, Augusto Orlandi, Maria Giovanni Scioli, Pietro Gentile

Research output: Contribution to journalArticle

Abstract

Developing cartilage constructs with injectability, appropriate matrix composition, and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. Fourteen patients with minor contour deformity were treated with fluid cartilage filler gently injected as autologous fluid graft in deep planes of defect of the nose that were close to the bone or the cartilage. A computerized tomographic scan control was performed after 12 months. Pearson's Chi-square test was used to investigate differences in cartilage density between native and newly formed cartilages. The endpoints were the possibility of using fluid cartilage as filler with aesthetic and functional improvement and versatility. Patients were followed up for two years. The constructs of fluid cartilage graft that were injected in the deep plane resulted in a persistent cartilage tissue with appropriate morphology, adequate central nutritional perfusion without central necrosis or ossification, and further augmented nasal dorsum without obvious contraction and deformation. This report demonstrated that fluid cartilage grafts are useful for cartilage regeneration in patients with outcomes of rhinoplasty, internal nasal valve collapse, and minor congenital nose aesthetics deformity.

Original languageEnglish
JournalMaterials
Volume12
Issue number7
DOIs
Publication statusPublished - Jan 1 2019

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Keywords

  • Crushing cartilage
  • Diced cartilage
  • Fluid cartilage
  • Minor nose defects
  • Rhinoplasty

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Trivisonno, A., Cohen, S. R., Magalon, G., Magalon, J., Sterodimas, A., Pascali, M., Cervelli, V., Toietta, G., Colaprietra, A., Calcagni, F., Orlandi, A., Scioli, M. G., & Gentile, P. (2019). Fluid cartilage as new autologous biomaterial in the treatment of minor nose defects: Clinical and microscopic difference amongst diced, crushed, and fluid cartilage. Materials, 12(7). https://doi.org/10.3390/ma12071062