Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Martine M. Ros, H. B. Bas Bueno-De-Mesquita, Frederike L. Büchner, Katja K H Aben, Ellen Kampman, Lars Egevad, Kim Overvad, Anne Tjãnneland, Nina Roswall, Francoise Clavel-Chapelon, Rudolf Kaaks, Jenny Chang-Claude, Heiner Boeing, Steffen Weikert, Antonia Trichopoulou, Philippos Orfanos, Georgia Stasinopulou, Calogero Saieva, Vittorio Krogh, Paolo VineisRosario Tumino, Amalia Mattiello, Petra H M Peeters, Fränzel J B Van Duijnhoven, Eiliv Lund, Inger T. Gram, Maria D. Chirlaque, Aurelio Barricarte, Laudina Rodríguez, Esther Molina, Carlos Gonzalez, Miren Dorronsoro, Jonas Manjer, Roy Ehrnström, Börje Ljungberg, Naomi E. Allen, Andrew W. Roddam, Kay Tee Khaw, Nick Wareham, Paolo Boffetta, Nadia Slimani, Dominique S. Michaud, Lambertus A L M Kiemeney, Elio Riboli

Research output: Contribution to journalArticle

Abstract

Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95%CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95%CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95%CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.

Original languageEnglish
Pages (from-to)2695-2708
Number of pages14
JournalInternational Journal of Cancer
Volume128
Issue number11
DOIs
Publication statusPublished - Jun 1 2011

Fingerprint

Carcinoma
Neoplasms
Smoking
Carbonated Beverages
Alcoholic Beverages
Coffee
Beverages
Tea
Energy Intake
Drinking
Milk
Food
Water

Keywords

  • bladder cancer
  • EPIC
  • fluid
  • urothelial cell carcinomas

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ros, M. M., Bas Bueno-De-Mesquita, H. B., Büchner, F. L., Aben, K. K. H., Kampman, E., Egevad, L., ... Riboli, E. (2011). Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). International Journal of Cancer, 128(11), 2695-2708. https://doi.org/10.1002/ijc.25592

Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). / Ros, Martine M.; Bas Bueno-De-Mesquita, H. B.; Büchner, Frederike L.; Aben, Katja K H; Kampman, Ellen; Egevad, Lars; Overvad, Kim; Tjãnneland, Anne; Roswall, Nina; Clavel-Chapelon, Francoise; Kaaks, Rudolf; Chang-Claude, Jenny; Boeing, Heiner; Weikert, Steffen; Trichopoulou, Antonia; Orfanos, Philippos; Stasinopulou, Georgia; Saieva, Calogero; Krogh, Vittorio; Vineis, Paolo; Tumino, Rosario; Mattiello, Amalia; Peeters, Petra H M; Van Duijnhoven, Fränzel J B; Lund, Eiliv; Gram, Inger T.; Chirlaque, Maria D.; Barricarte, Aurelio; Rodríguez, Laudina; Molina, Esther; Gonzalez, Carlos; Dorronsoro, Miren; Manjer, Jonas; Ehrnström, Roy; Ljungberg, Börje; Allen, Naomi E.; Roddam, Andrew W.; Khaw, Kay Tee; Wareham, Nick; Boffetta, Paolo; Slimani, Nadia; Michaud, Dominique S.; Kiemeney, Lambertus A L M; Riboli, Elio.

In: International Journal of Cancer, Vol. 128, No. 11, 01.06.2011, p. 2695-2708.

Research output: Contribution to journalArticle

Ros, MM, Bas Bueno-De-Mesquita, HB, Büchner, FL, Aben, KKH, Kampman, E, Egevad, L, Overvad, K, Tjãnneland, A, Roswall, N, Clavel-Chapelon, F, Kaaks, R, Chang-Claude, J, Boeing, H, Weikert, S, Trichopoulou, A, Orfanos, P, Stasinopulou, G, Saieva, C, Krogh, V, Vineis, P, Tumino, R, Mattiello, A, Peeters, PHM, Van Duijnhoven, FJB, Lund, E, Gram, IT, Chirlaque, MD, Barricarte, A, Rodríguez, L, Molina, E, Gonzalez, C, Dorronsoro, M, Manjer, J, Ehrnström, R, Ljungberg, B, Allen, NE, Roddam, AW, Khaw, KT, Wareham, N, Boffetta, P, Slimani, N, Michaud, DS, Kiemeney, LALM & Riboli, E 2011, 'Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)', International Journal of Cancer, vol. 128, no. 11, pp. 2695-2708. https://doi.org/10.1002/ijc.25592
Ros, Martine M. ; Bas Bueno-De-Mesquita, H. B. ; Büchner, Frederike L. ; Aben, Katja K H ; Kampman, Ellen ; Egevad, Lars ; Overvad, Kim ; Tjãnneland, Anne ; Roswall, Nina ; Clavel-Chapelon, Francoise ; Kaaks, Rudolf ; Chang-Claude, Jenny ; Boeing, Heiner ; Weikert, Steffen ; Trichopoulou, Antonia ; Orfanos, Philippos ; Stasinopulou, Georgia ; Saieva, Calogero ; Krogh, Vittorio ; Vineis, Paolo ; Tumino, Rosario ; Mattiello, Amalia ; Peeters, Petra H M ; Van Duijnhoven, Fränzel J B ; Lund, Eiliv ; Gram, Inger T. ; Chirlaque, Maria D. ; Barricarte, Aurelio ; Rodríguez, Laudina ; Molina, Esther ; Gonzalez, Carlos ; Dorronsoro, Miren ; Manjer, Jonas ; Ehrnström, Roy ; Ljungberg, Börje ; Allen, Naomi E. ; Roddam, Andrew W. ; Khaw, Kay Tee ; Wareham, Nick ; Boffetta, Paolo ; Slimani, Nadia ; Michaud, Dominique S. ; Kiemeney, Lambertus A L M ; Riboli, Elio. / Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). In: International Journal of Cancer. 2011 ; Vol. 128, No. 11. pp. 2695-2708.
@article{e7e87596eb3d46c8a6d1bbf5e7fd1b4a,
title = "Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)",
abstract = "Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95{\%}CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95{\%}CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95{\%}CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.",
keywords = "bladder cancer, EPIC, fluid, urothelial cell carcinomas",
author = "Ros, {Martine M.} and {Bas Bueno-De-Mesquita}, {H. B.} and B{\"u}chner, {Frederike L.} and Aben, {Katja K H} and Ellen Kampman and Lars Egevad and Kim Overvad and Anne Tj{\~a}nneland and Nina Roswall and Francoise Clavel-Chapelon and Rudolf Kaaks and Jenny Chang-Claude and Heiner Boeing and Steffen Weikert and Antonia Trichopoulou and Philippos Orfanos and Georgia Stasinopulou and Calogero Saieva and Vittorio Krogh and Paolo Vineis and Rosario Tumino and Amalia Mattiello and Peeters, {Petra H M} and {Van Duijnhoven}, {Fr{\"a}nzel J B} and Eiliv Lund and Gram, {Inger T.} and Chirlaque, {Maria D.} and Aurelio Barricarte and Laudina Rodr{\'i}guez and Esther Molina and Carlos Gonzalez and Miren Dorronsoro and Jonas Manjer and Roy Ehrnstr{\"o}m and B{\"o}rje Ljungberg and Allen, {Naomi E.} and Roddam, {Andrew W.} and Khaw, {Kay Tee} and Nick Wareham and Paolo Boffetta and Nadia Slimani and Michaud, {Dominique S.} and Kiemeney, {Lambertus A L M} and Elio Riboli",
year = "2011",
month = "6",
day = "1",
doi = "10.1002/ijc.25592",
language = "English",
volume = "128",
pages = "2695--2708",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "11",

}

TY - JOUR

T1 - Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)

AU - Ros, Martine M.

AU - Bas Bueno-De-Mesquita, H. B.

AU - Büchner, Frederike L.

AU - Aben, Katja K H

AU - Kampman, Ellen

AU - Egevad, Lars

AU - Overvad, Kim

AU - Tjãnneland, Anne

AU - Roswall, Nina

AU - Clavel-Chapelon, Francoise

AU - Kaaks, Rudolf

AU - Chang-Claude, Jenny

AU - Boeing, Heiner

AU - Weikert, Steffen

AU - Trichopoulou, Antonia

AU - Orfanos, Philippos

AU - Stasinopulou, Georgia

AU - Saieva, Calogero

AU - Krogh, Vittorio

AU - Vineis, Paolo

AU - Tumino, Rosario

AU - Mattiello, Amalia

AU - Peeters, Petra H M

AU - Van Duijnhoven, Fränzel J B

AU - Lund, Eiliv

AU - Gram, Inger T.

AU - Chirlaque, Maria D.

AU - Barricarte, Aurelio

AU - Rodríguez, Laudina

AU - Molina, Esther

AU - Gonzalez, Carlos

AU - Dorronsoro, Miren

AU - Manjer, Jonas

AU - Ehrnström, Roy

AU - Ljungberg, Börje

AU - Allen, Naomi E.

AU - Roddam, Andrew W.

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Boffetta, Paolo

AU - Slimani, Nadia

AU - Michaud, Dominique S.

AU - Kiemeney, Lambertus A L M

AU - Riboli, Elio

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95%CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95%CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95%CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.

AB - Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95%CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95%CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95%CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.

KW - bladder cancer

KW - EPIC

KW - fluid

KW - urothelial cell carcinomas

UR - http://www.scopus.com/inward/record.url?scp=79953309327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953309327&partnerID=8YFLogxK

U2 - 10.1002/ijc.25592

DO - 10.1002/ijc.25592

M3 - Article

C2 - 20715171

AN - SCOPUS:79953309327

VL - 128

SP - 2695

EP - 2708

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 11

ER -