Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Martine M. Ros, H. B. Bas Bueno-De-Mesquita, Frederike L. Büchner, Katja K H Aben, Ellen Kampman, Lars Egevad, Kim Overvad, Anne Tjãnneland, Nina Roswall, Francoise Clavel-Chapelon, Rudolf Kaaks, Jenny Chang-Claude, Heiner Boeing, Steffen Weikert, Antonia Trichopoulou, Philippos Orfanos, Georgia Stasinopulou, Calogero Saieva, Vittorio Krogh, Paolo VineisRosario Tumino, Amalia Mattiello, Petra H M Peeters, Fränzel J B Van Duijnhoven, Eiliv Lund, Inger T. Gram, Maria D. Chirlaque, Aurelio Barricarte, Laudina Rodríguez, Esther Molina, Carlos Gonzalez, Miren Dorronsoro, Jonas Manjer, Roy Ehrnström, Börje Ljungberg, Naomi E. Allen, Andrew W. Roddam, Kay Tee Khaw, Nick Wareham, Paolo Boffetta, Nadia Slimani, Dominique S. Michaud, Lambertus A L M Kiemeney, Elio Riboli

Research output: Contribution to journalArticle

Abstract

Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95%CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95%CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95%CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.

Original languageEnglish
Pages (from-to)2695-2708
Number of pages14
JournalInternational Journal of Cancer
Volume128
Issue number11
DOIs
Publication statusPublished - Jun 1 2011

Keywords

  • bladder cancer
  • EPIC
  • fluid
  • urothelial cell carcinomas

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Ros, M. M., Bas Bueno-De-Mesquita, H. B., Büchner, F. L., Aben, K. K. H., Kampman, E., Egevad, L., Overvad, K., Tjãnneland, A., Roswall, N., Clavel-Chapelon, F., Kaaks, R., Chang-Claude, J., Boeing, H., Weikert, S., Trichopoulou, A., Orfanos, P., Stasinopulou, G., Saieva, C., Krogh, V., ... Riboli, E. (2011). Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC). International Journal of Cancer, 128(11), 2695-2708. https://doi.org/10.1002/ijc.25592