Fluid overload syndrome: A potentially life-threatening complication of Thulium Laser Enucleation of the Prostate

Daniele Castellani, Luca Gasparri, Lucia Faloia, Diego Veccia, Marina Giampieri, Marco Dellabella

Research output: Contribution to journalArticlepeer-review


Systemic fluid absorption frequently occurs during endoscopic surgery. When large volumes are absorbed, fluid overload is the result. The introduction of lasers allowed the use of normal saline (0.9% sodium chloride) in endoscopic prostatic surgery. This led to the disappearance of the transurethral resection syndrome; however, the fluid overload of normal saline can cause the onset of several catastrophic effects. The present study aimed to evaluate the incidence, sign and symptoms severity of fluid overload in a large series of men who underwent Thulium Laser Enucleation of the Prostate. Between December 2014 and February 2020, 633 men underwent the procedure. Seven patients (1.1%) had symptomatic fluid overload. Two patients developed severe pulmonary oedema, which required oral intubation and admission to the intensive care unit. Two patients required delayed morcellation. The analysis of our series highlighted that old age, large prostate volume, prolonged operative time and prostatic capsular perforation influenced the onset of fluid overload syndrome. Urologists should be aware that fluid overload might be a potentially life-threatening condition and should be early recognised. Surgery should be interrupted as soon as it occurs to avoid severe pulmonary oedema.

Original languageEnglish
Article numbere13807
Issue number1
Publication statusPublished - Feb 2021


  • absorption
  • intraoperative complications
  • laser therapy
  • prostatectomy
  • saline solution
  • transurethral

ASJC Scopus subject areas

  • Endocrinology
  • Urology


Dive into the research topics of 'Fluid overload syndrome: A potentially life-threatening complication of Thulium Laser Enucleation of the Prostate'. Together they form a unique fingerprint.

Cite this