Flunarizine in migraine: A minireview

M. Leone, L. Grazzi, L. La Mantia, G. Bussone

Research output: Contribution to journalArticlepeer-review


Flunarizine is a non-selective calcium antagonist. It distributes preferentially in the adipose tissue and passes the blood brain barrier. Numerous controlled clinical studies have established that flunarizine is efficacious in migraine prophylaxis, including double-blind studies in which the drug was compared with placebo or other antimigraine drugs. To avoid side effects a special schedule or administration is necessary. Flunarizine has no myogenic effect on smooth muscle cells of the vessles. It is said to be the only calicum antagonist able to protect brain cells against hypoxic damage. In addition, the considerable body of information which shows flunarizine capable of directly influencing the central nervous system, suggests that the drug's anti-migraine action may depend on its ability to influence central phenomena.

Original languageEnglish
Pages (from-to)388-391
Number of pages4
Issue number6
Publication statusPublished - 1991


  • flunarizine
  • migraine
  • prophylaxis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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