Diagnosi di membrane neovascolari sottoretiniche mediante fluorangiografia e angiografia con verde di indocianina

Translated title of the contribution: Fluorescein and indocyanine green angiography in the diagnosis of coroideal neovascolarization

G. Vandelli, E. Giacomotti, F. Nozza

Research output: Contribution to journalArticle

Abstract

This study has been performed to valuate if indocyanine green angiography (ICGA) is an important complemental method to fluorescein angiography (FA) in the detection of choroidal neovascolarizations (CNV). We retrospectively evaluated 147 eyes affected by age-related macular degeneration (ARMD) and myopic macular degeneration (MMD) seen in the Ophthalmic Clinic of S. Matteo Hospital - Pavia (Italy). We performed FA and ICGA in 73 patients with ARMD (30 men and 43 women) and 23 with MMD (8 men and 15 women) between January 1998 and September 2000. The average age was 72.1±7.0 years for ARMD and 54,4±15,0 for MMD. Before angiography, each patient had an ophthalmologic and retinal examination by slitlamp biomicroscopy. We used a Topcon IMAGEnet TRC 50IA Digital Imaging System. FA was performed by injecting 5 ml of sodium fluorescein 20% into the antecubital vein of the arm; ICGA was performed by injecting 25 mg of ICG (IC-GREEN, Akorn Inc.) in a 5 ml watery solvent followed by a 5 ml bolus of balanced salt solution. CNVs were detected in 77 (64.7%) of the 119 eyes which had macular lesions of ARMD and in 19 of the 28 (67,9%) eyes affected by myopic degeneration. As regards ARMD, ICGA confirmed the presence of well-defined CNVs in 20 eyes and revealed occult CNVs in 57 on 99 eyes (57,6%), whereas fluorescein angiograms only indicated findings suspicious of abnormal vessels or revealed no evidence of CNVs. A regards MD, FA revealed 8 well-defined CNVs, while ICGA detected 11 occult CNVs on 20 FAG-negative cases (55,0%). The results of this study show that ICGA is an important technique in the diagnosis, classification and treatment of occult CNVs and may be considered as a fundamental complementary method to FA, even if FA is more sensitive in delineating well-defined CNVs.

Original languageItalian
Pages (from-to)201-215
Number of pages15
JournalAnnali di Ottalmologia e Clinica Oculistica
Volume126
Issue number11-12
Publication statusPublished - 2000

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Indocyanine Green
Macular Degeneration
Fluorescein
Fluorescein Angiography
Angiography
Italy
Veins
Arm
Salts

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Diagnosi di membrane neovascolari sottoretiniche mediante fluorangiografia e angiografia con verde di indocianina. / Vandelli, G.; Giacomotti, E.; Nozza, F.

In: Annali di Ottalmologia e Clinica Oculistica, Vol. 126, No. 11-12, 2000, p. 201-215.

Research output: Contribution to journalArticle

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