Fluorescein angiography and indocyanine green angiography for identifying occult choroidal neovascularization in age-related macular degeneration

Alfredo Pece, C. Sannace, U. Menchini, G. Virgili, L. Galli, V. Isola, R. Brancato

Research output: Contribution to journalArticle

Abstract

PURPOSE. To assess whether fluorescein angiography (FA) alone without indocyanine green angiography (ICGA) can identify and localize occult choroidal neovascularization (CNV) in age-related macular degeneration (ARMD). METHODS. Seventy-nine eyes of 77 consecutive patients with occult CNV were evaluated independently by two skilled physicians at first with FA alone and then with FA combined with ICGA by fundus camera. RESULTS. The agreement between FA and ICGA was 73% and 68% for the two physicians (K=0.585 and 0.512, respectively). The first operator correctly identified 20/27 as plaque CNV; six had different sizes and locations. The second operator identified 25/30, with one mistaken for size and location. For focal CNV the first operator identified 34/39, and the second one 23/35. CONCLUSIONS. Comparing the FA results with ICGA, CNV was correctly identified in about 60% of cases. Therefore, ICGA should be considered an indispensable diagnostic test to identify the presence, the type, and the location of occult CNV.

Original languageEnglish
Pages (from-to)759-763
Number of pages5
JournalEuropean Journal of Ophthalmology
Volume15
Issue number6
Publication statusPublished - Nov 2005

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Choroidal Neovascularization
Indocyanine Green
Fluorescein Angiography
Macular Degeneration
Angiography
Physicians
Routine Diagnostic Tests

Keywords

  • Age-related macular degeneration
  • Fluorescein angiography
  • Indocyanine green angiography
  • Occult CNV

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Fluorescein angiography and indocyanine green angiography for identifying occult choroidal neovascularization in age-related macular degeneration. / Pece, Alfredo; Sannace, C.; Menchini, U.; Virgili, G.; Galli, L.; Isola, V.; Brancato, R.

In: European Journal of Ophthalmology, Vol. 15, No. 6, 11.2005, p. 759-763.

Research output: Contribution to journalArticle

Pece, Alfredo ; Sannace, C. ; Menchini, U. ; Virgili, G. ; Galli, L. ; Isola, V. ; Brancato, R. / Fluorescein angiography and indocyanine green angiography for identifying occult choroidal neovascularization in age-related macular degeneration. In: European Journal of Ophthalmology. 2005 ; Vol. 15, No. 6. pp. 759-763.
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AU - Pece, Alfredo

AU - Sannace, C.

AU - Menchini, U.

AU - Virgili, G.

AU - Galli, L.

AU - Isola, V.

AU - Brancato, R.

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N2 - PURPOSE. To assess whether fluorescein angiography (FA) alone without indocyanine green angiography (ICGA) can identify and localize occult choroidal neovascularization (CNV) in age-related macular degeneration (ARMD). METHODS. Seventy-nine eyes of 77 consecutive patients with occult CNV were evaluated independently by two skilled physicians at first with FA alone and then with FA combined with ICGA by fundus camera. RESULTS. The agreement between FA and ICGA was 73% and 68% for the two physicians (K=0.585 and 0.512, respectively). The first operator correctly identified 20/27 as plaque CNV; six had different sizes and locations. The second operator identified 25/30, with one mistaken for size and location. For focal CNV the first operator identified 34/39, and the second one 23/35. CONCLUSIONS. Comparing the FA results with ICGA, CNV was correctly identified in about 60% of cases. Therefore, ICGA should be considered an indispensable diagnostic test to identify the presence, the type, and the location of occult CNV.

AB - PURPOSE. To assess whether fluorescein angiography (FA) alone without indocyanine green angiography (ICGA) can identify and localize occult choroidal neovascularization (CNV) in age-related macular degeneration (ARMD). METHODS. Seventy-nine eyes of 77 consecutive patients with occult CNV were evaluated independently by two skilled physicians at first with FA alone and then with FA combined with ICGA by fundus camera. RESULTS. The agreement between FA and ICGA was 73% and 68% for the two physicians (K=0.585 and 0.512, respectively). The first operator correctly identified 20/27 as plaque CNV; six had different sizes and locations. The second operator identified 25/30, with one mistaken for size and location. For focal CNV the first operator identified 34/39, and the second one 23/35. CONCLUSIONS. Comparing the FA results with ICGA, CNV was correctly identified in about 60% of cases. Therefore, ICGA should be considered an indispensable diagnostic test to identify the presence, the type, and the location of occult CNV.

KW - Age-related macular degeneration

KW - Fluorescein angiography

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KW - Occult CNV

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