Fluorescein angiography and spectral-domain optical coherence tomography for monitoring Anti-VEGF therapy in myopic choroidal neovascularization

Pierluigi Iacono, Maurizio Battaglia Parodi, Alexandros Papayannis, Stylianos Kontadakis, Stefano Da Pozzo, Maria Lucia Cascavilla, Carlo La Spina, Monica Varano, Francesco Bandello

Research output: Contribution to journalArticlepeer-review


Aim: To evaluate the agreement between fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD-OCT) in detecting myopic choroidal neovascularization (CNV) activity during bevacizumab treatment. Methods: Thirty-four patients with subfoveal myopic CNV were prospectively enrolled. FA and SD-OCT were performed at baseline and at all planned monthly visits. After the first injection, additional treatments were administered following detection of fluid on SD-OCT and/or leakage on FA. κ-Analysis was performed to examine the agreement between FA and SD-OCT. Results: At baseline, FA and SD-OCT agreed in 26/34 cases (κ = 0.23); sensitivity and specificity were 77.4 and 66.7%, respectively. Seven eyes presented leakage on FA with no fluid on SD-OCT, 1 case showed intraretinal fluid on SD-OCT and no leakage on FA. At the 1-month examination, specificity and κ-value improved, and 30/34 cases showed complete concordance. At the 3- and 4-month examinations, a discordance was noted in 6 cases. From the 5-month examination on, a correspondence was achieved in at least 30/34 cases and reached a perfect match in 11 sessions. Conclusions: Our study confirms the key role of FA in diagnosing myopic CNV. It seems possible there may be a role for SD-OCT in assisting FA to monitor the myopic CNV activity during anti-vascular endothelial growth factor antibody treatment.

Original languageEnglish
Pages (from-to)25-31
Number of pages7
JournalOphthalmic Research
Issue number1
Publication statusPublished - 2014


  • Anti-vascular endothelial growth factor antibody
  • Intravitreal bevacizumab
  • Pathological myopia
  • Spectral-domain optical coherence tomography
  • Subfoveal myopic choroidal neovascularization

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)


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