Fluoreszenzdiagnostik bei patienten mit nicht muskelinvasivem harnblasenkarzinom: Ergebnisse einer metaanalyse

I. Kausch; M. Sommerauer; F. Montorsi; A. Stenzl; D. Jacqmin; P. Jichlinski; D. Jocham; A. Ziegler; R. Vonthein

doi:10.1055/s-0030-1247363

Fluoreszenzdiagnostik bei patienten mit nicht muskelinvasivem harnblasenkarzinom: Ergebnisse einer metaanalyse

Translated title of the contribution: Fluorescence diagnosis in patients with non-muscle invasive bladder cancer: Results of a metaanalysis

I. Kausch, M. Sommerauer, F. Montorsi, A. Stenzl, D. Jacqmin, P. Jichlinski, D. Jocham, A. Ziegler, R. Vonthein

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose:Heterogeneous results of single studies with photodynamic diagnosis (PDD) in bladder cancer have been reported. A metaanalysis of prospective studies has now been performed. Material and Methods:The effect of PDD in addition to WLC on a)the diagnosis and b)the therapeutic outcome of primary or recurrent non-muscle invasive bladder cancer (NMIBC) investigated by cystoscopy or transurethral resection was analysed. An electronic database search was performed. Trials were included if they prospectively compared WLC with PDD in bladder cancer. Primary endpoints were additional detection rate, residual tumour at second resection and recurrence-free survival. Results:Significantly more tumour-positive patients were detected with PDD in all patients with non-muscle invasive tumours (=20%) [95% confidence interval (CI): 8 to 35%] and in CIS patients (=39%) (CI: 23 to 57%). Residual tumour was significantly less often found after PDD (odds ratio 0.28, CI: 0.15 to 0.52, p

Translated title of the contribution	Fluorescence diagnosis in patients with non-muscle invasive bladder cancer: Results of a metaanalysis
Original language	German
Pages (from-to)	171-177
Number of pages	7
Journal	Aktuelle Urologie
Volume	41
Issue number	3
DOIs	https://doi.org/10.1055/s-0030-1247363
Publication status	Published - 2010

Keywords

5-aminolevulinic acid
ALA
Bladder cancer
Bladder neoplasms
HAL
Hexaminolevulinate
Metaanalysis
PDD
Transurethral resection
TUR

ASJC Scopus subject areas

Urology
Medicine(all)

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title = "Fluoreszenzdiagnostik bei patienten mit nicht muskelinvasivem harnblasenkarzinom: Ergebnisse einer metaanalyse",

abstract = "Purpose:Heterogeneous results of single studies with photodynamic diagnosis (PDD) in bladder cancer have been reported. A metaanalysis of prospective studies has now been performed. Material and Methods:The effect of PDD in addition to WLC on a)the diagnosis and b)the therapeutic outcome of primary or recurrent non-muscle invasive bladder cancer (NMIBC) investigated by cystoscopy or transurethral resection was analysed. An electronic database search was performed. Trials were included if they prospectively compared WLC with PDD in bladder cancer. Primary endpoints were additional detection rate, residual tumour at second resection and recurrence-free survival. Results:Significantly more tumour-positive patients were detected with PDD in all patients with non-muscle invasive tumours (=20%) [95% confidence interval (CI): 8 to 35%] and in CIS patients (=39%) (CI: 23 to 57%). Residual tumour was significantly less often found after PDD (odds ratio 0.28, CI: 0.15 to 0.52, p",

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doi = "10.1055/s-0030-1247363",

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AU - Kausch, I.

AU - Sommerauer, M.

AU - Montorsi, F.

AU - Stenzl, A.

AU - Jacqmin, D.

AU - Jichlinski, P.

AU - Jocham, D.

AU - Ziegler, A.

AU - Vonthein, R.

PY - 2010

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N2 - Purpose:Heterogeneous results of single studies with photodynamic diagnosis (PDD) in bladder cancer have been reported. A metaanalysis of prospective studies has now been performed. Material and Methods:The effect of PDD in addition to WLC on a)the diagnosis and b)the therapeutic outcome of primary or recurrent non-muscle invasive bladder cancer (NMIBC) investigated by cystoscopy or transurethral resection was analysed. An electronic database search was performed. Trials were included if they prospectively compared WLC with PDD in bladder cancer. Primary endpoints were additional detection rate, residual tumour at second resection and recurrence-free survival. Results:Significantly more tumour-positive patients were detected with PDD in all patients with non-muscle invasive tumours (=20%) [95% confidence interval (CI): 8 to 35%] and in CIS patients (=39%) (CI: 23 to 57%). Residual tumour was significantly less often found after PDD (odds ratio 0.28, CI: 0.15 to 0.52, p

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Fluoreszenzdiagnostik bei patienten mit nicht muskelinvasivem harnblasenkarzinom: Ergebnisse einer metaanalyse

Abstract

Keywords

ASJC Scopus subject areas

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