Abstract
Purpose:Heterogeneous results of single studies with photodynamic diagnosis (PDD) in bladder cancer have been reported. A metaanalysis of prospective studies has now been performed. Material and Methods:The effect of PDD in addition to WLC on a)the diagnosis and b)the therapeutic outcome of primary or recurrent non-muscle invasive bladder cancer (NMIBC) investigated by cystoscopy or transurethral resection was analysed. An electronic database search was performed. Trials were included if they prospectively compared WLC with PDD in bladder cancer. Primary endpoints were additional detection rate, residual tumour at second resection and recurrence-free survival. Results:Significantly more tumour-positive patients were detected with PDD in all patients with non-muscle invasive tumours (=20%) [95% confidence interval (CI): 8 to 35%] and in CIS patients (=39%) (CI: 23 to 57%). Residual tumour was significantly less often found after PDD (odds ratio 0.28, CI: 0.15 to 0.52, p
Translated title of the contribution | Fluorescence diagnosis in patients with non-muscle invasive bladder cancer: Results of a metaanalysis |
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Original language | German |
Pages (from-to) | 171-177 |
Number of pages | 7 |
Journal | Aktuelle Urologie |
Volume | 41 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2010 |
Keywords
- 5-aminolevulinic acid
- ALA
- Bladder cancer
- Bladder neoplasms
- HAL
- Hexaminolevulinate
- Metaanalysis
- PDD
- Transurethral resection
- TUR
ASJC Scopus subject areas
- Urology
- Medicine(all)