Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease

Cristina Airoldi, Francisco Cardona, Erika Sironi, Laura Colombo, Mario Salmona, Ilaria Cambianica, Francesca Ornaghi, Giulio Sancini, Francesco Nicotra, Barbara La Ferla

Research output: Contribution to journalArticle

Abstract

Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluores cently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood-brain barrier (BBB) and to stain Aβ-deposits.

Original languageEnglish
Pages (from-to)1813-1823
Number of pages11
JournalPure and Applied Chemistry
Volume85
Issue number9
DOIs
Publication statusPublished - 2013

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Keywords

  • Aβ-peptide ligands
  • Alzheimer's disease
  • Fluorescent derivatives
  • Glycofused compounds

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Airoldi, C., Cardona, F., Sironi, E., Colombo, L., Salmona, M., Cambianica, I., Ornaghi, F., Sancini, G., Nicotra, F., & La Ferla, B. (2013). Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease. Pure and Applied Chemistry, 85(9), 1813-1823. https://doi.org/10.1351/PAC-CON-12-11-07