Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease

Cristina Airoldi; Francisco Cardona; Erika Sironi; Laura Colombo; Mario Salmona; Ilaria Cambianica; Francesca Ornaghi; Giulio Sancini; Francesco Nicotra; Barbara La Ferla

doi:10.1351/PAC-CON-12-11-07

Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease

Cristina Airoldi, Francisco Cardona, Erika Sironi, Laura Colombo, Mario Salmona, Ilaria Cambianica, Francesca Ornaghi, Giulio Sancini, Francesco Nicotra, Barbara La Ferla

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article

Abstract

Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluores cently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood-brain barrier (BBB) and to stain Aβ-deposits.

Original language	English
Pages (from-to)	1813-1823
Number of pages	11
Journal	Pure and Applied Chemistry
Volume	85
Issue number	9
DOIs	https://doi.org/10.1351/PAC-CON-12-11-07
Publication status	Published - 2013

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Keywords

Aβ-peptide ligands
Alzheimer's disease
Fluorescent derivatives
Glycofused compounds

ASJC Scopus subject areas

Chemical Engineering(all)
Chemistry(all)

Cite this

Airoldi, C., Cardona, F., Sironi, E., Colombo, L., Salmona, M., Cambianica, I., Ornaghi, F., Sancini, G., Nicotra, F., & La Ferla, B. (2013). Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease. Pure and Applied Chemistry, 85(9), 1813-1823. https://doi.org/10.1351/PAC-CON-12-11-07

Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease. / Airoldi, Cristina; Cardona, Francisco; Sironi, Erika; Colombo, Laura ; Salmona, Mario; Cambianica, Ilaria; Ornaghi, Francesca; Sancini, Giulio; Nicotra, Francesco; La Ferla, Barbara.

In: Pure and Applied Chemistry, Vol. 85, No. 9, 2013, p. 1813-1823.

Research output: Contribution to journal › Article

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Access to Document

10.1351/PAC-CON-12-11-07