Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease

Cristina Airoldi; Francisco Cardona; Erika Sironi; Laura Colombo; Mario Salmona; Ilaria Cambianica; Francesca Ornaghi; Giulio Sancini; Francesco Nicotra; Barbara La Ferla

doi:10.1351/PAC-CON-12-11-07

Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease

Cristina Airoldi, Francisco Cardona, Erika Sironi, Laura Colombo, Mario Salmona, Ilaria Cambianica, Francesca Ornaghi, Giulio Sancini, Francesco Nicotra, Barbara La Ferla

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluores cently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood-brain barrier (BBB) and to stain Aβ-deposits.

Original language	English
Pages (from-to)	1813-1823
Number of pages	11
Journal	Pure and Applied Chemistry
Volume	85
Issue number	9
DOIs	https://doi.org/10.1351/PAC-CON-12-11-07
Publication status	Published - 2013

Keywords

Aβ-peptide ligands
Alzheimer's disease
Fluorescent derivatives
Glycofused compounds

ASJC Scopus subject areas

Chemical Engineering(all)
Chemistry(all)

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10.1351/PAC-CON-12-11-07

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title = "Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease",

abstract = "Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluores cently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood-brain barrier (BBB) and to stain Aβ-deposits.",

keywords = "Aβ-peptide ligands, Alzheimer's disease, Fluorescent derivatives, Glycofused compounds",

author = "Cristina Airoldi and Francisco Cardona and Erika Sironi and Laura Colombo and Mario Salmona and Ilaria Cambianica and Francesca Ornaghi and Giulio Sancini and Francesco Nicotra and {La Ferla}, Barbara",

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T1 - Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease

AU - Airoldi, Cristina

AU - Cardona, Francisco

AU - Sironi, Erika

AU - Colombo, Laura

AU - Salmona, Mario

AU - Cambianica, Ilaria

AU - Ornaghi, Francesca

AU - Sancini, Giulio

AU - Nicotra, Francesco

AU - La Ferla, Barbara

PY - 2013

Y1 - 2013

N2 - Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluores cently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood-brain barrier (BBB) and to stain Aβ-deposits.

AB - Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluores cently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood-brain barrier (BBB) and to stain Aβ-deposits.

KW - Aβ-peptide ligands

KW - Alzheimer's disease

KW - Fluorescent derivatives

KW - Glycofused compounds

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JO - Pure and Applied Chemistry

JF - Pure and Applied Chemistry

SN - 0033-4545

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ER -

Fluorescent amyloid β-peptide ligand derivatives as potential diagnostic tools for Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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