Abstract
Aβ-peptide ligands based on a cis-glycofused benzopyran structure have been fluores cently labeled using coumarine derivatives. Among the synthesized compounds, two conserved their binding ability to β-amyloid peptides, as shown by NMR experiments. Moreover, exploiting its fluorescent property, it was demonstrated that one of such compounds was able to cross an in vitro model of blood-brain barrier (BBB) and to stain Aβ-deposits.
Original language | English |
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Pages (from-to) | 1813-1823 |
Number of pages | 11 |
Journal | Pure and Applied Chemistry |
Volume | 85 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2013 |
Keywords
- Aβ-peptide ligands
- Alzheimer's disease
- Fluorescent derivatives
- Glycofused compounds
ASJC Scopus subject areas
- Chemical Engineering(all)
- Chemistry(all)