Fluorescent imaging of vascular shutdown in-vivo

Gianluca Valentini, Cosimo D'Andrea, Raffaele Ferrari, Antonio Pifferi, Rinaldo Cubeddu, Michele Martinelli, Claudia Natoli, Paolo Ubezio, Raffaella Giavazzi

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We demonstrated that fluorescence imaging with Indocyanine Green marker can be used to measure the volume of the active vasculature in tumor models implanted in nude mice. Tumors expressing the Vascular Growth Factor showed an enhanced fluorescence, while tumors treated with a Vascular Damaging Agent gave a strongly depleted signal, which confirmed an effective vascular shutdown.

Original languageEnglish
Title of host publicationOptics InfoBase Conference Papers
PublisherOptical Society of America
ISBN (Print)1557528071, 9781557528070
Publication statusPublished - 2006
EventBiomedical Topical Meeting, BIO 2006 - Fort Lauderdale, FL, United States
Duration: Mar 19 2006Mar 19 2006


OtherBiomedical Topical Meeting, BIO 2006
CountryUnited States
CityFort Lauderdale, FL

ASJC Scopus subject areas

  • Instrumentation
  • Atomic and Molecular Physics, and Optics

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