Fluorescent imaging of vascular shutdown in-vivo

Gianluca Valentini; Cosimo D'Andrea; Raffaele Ferrari; Antonio Pifferi; Rinaldo Cubeddu; Michele Martinelli; Claudia Natoli; Paolo Ubezio; Raffaella Giavazzi

Fluorescent imaging of vascular shutdown in-vivo

Gianluca Valentini, Cosimo D'Andrea, Raffaele Ferrari, Antonio Pifferi, Rinaldo Cubeddu, Michele Martinelli, Claudia Natoli, Paolo Ubezio, Raffaella Giavazzi

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We demonstrated that fluorescence imaging with Indocyanine Green marker can be used to measure the volume of the active vasculature in tumor models implanted in nude mice. Tumors expressing the Vascular Growth Factor showed an enhanced fluorescence, while tumors treated with a Vascular Damaging Agent gave a strongly depleted signal, which confirmed an effective vascular shutdown.

Original language	English
Title of host publication	Optics InfoBase Conference Papers
Publisher	Optical Society of America
ISBN (Print)	1557528071, 9781557528070
Publication status	Published - 2006
Event	Biomedical Topical Meeting, BIO 2006 - Fort Lauderdale, FL, United States Duration: Mar 19 2006 → Mar 19 2006

Other

Other	Biomedical Topical Meeting, BIO 2006
Country	United States
City	Fort Lauderdale, FL
Period	3/19/06 → 3/19/06

ASJC Scopus subject areas

Instrumentation
Atomic and Molecular Physics, and Optics

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Fluorescent imaging of vascular shutdown in-vivo. / Valentini, Gianluca; D'Andrea, Cosimo; Ferrari, Raffaele; Pifferi, Antonio; Cubeddu, Rinaldo; Martinelli, Michele; Natoli, Claudia; Ubezio, Paolo ; Giavazzi, Raffaella.

Optics InfoBase Conference Papers. Optical Society of America, 2006.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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abstract = "We demonstrated that fluorescence imaging with Indocyanine Green marker can be used to measure the volume of the active vasculature in tumor models implanted in nude mice. Tumors expressing the Vascular Growth Factor showed an enhanced fluorescence, while tumors treated with a Vascular Damaging Agent gave a strongly depleted signal, which confirmed an effective vascular shutdown.",

author = "Gianluca Valentini and Cosimo D'Andrea and Raffaele Ferrari and Antonio Pifferi and Rinaldo Cubeddu and Michele Martinelli and Claudia Natoli and Paolo Ubezio and Raffaella Giavazzi",

year = "2006",

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AU - Valentini, Gianluca

AU - D'Andrea, Cosimo

AU - Ferrari, Raffaele

AU - Pifferi, Antonio

AU - Cubeddu, Rinaldo

AU - Martinelli, Michele

AU - Natoli, Claudia

AU - Ubezio, Paolo

AU - Giavazzi, Raffaella

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AB - We demonstrated that fluorescence imaging with Indocyanine Green marker can be used to measure the volume of the active vasculature in tumor models implanted in nude mice. Tumors expressing the Vascular Growth Factor showed an enhanced fluorescence, while tumors treated with a Vascular Damaging Agent gave a strongly depleted signal, which confirmed an effective vascular shutdown.

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