Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases

Isabella Castellano, Anna Sapino, Riccardo Arisio, Giuseppe Viale, Gianni Bussolati, Roberto Bandelloni, Gaetano Barresi, Alessandra Bersiga, Cesare Bordi, Gerardo Botti, Fabia Cosimi, Emanuele D'Amore, Claudio Doglioni, Antonio Marchetti, Oscar Nappi, Francesco Romeo, Massimo Roncalli, Rosa Russo, Alfredo Santinelli, Luigi Giusto SpagnoliFrancesco Tanda, Paolo Tricomi, Gianpaolo Trentini, Fabrizio Zanconati, Monica Iurlaro

Research output: Contribution to journalArticle

Abstract

The aim of the present study was to evaluate the effectiveness of fluorescence in situ hybridisation (FISH), as a screening test, in moderately- (G2) or poorly- (G3) differentiated breast cancers of the ductal (IDC) and lobular (ILC) histotypes and distant metastases. HER2 FISH was performed on 486 G2 and 477 G3 both of IDC and ILC histotypes and in 241 metastases. A significant difference in the HER2 amplification was observed between G2 (14.8%) and G3 (31.9%), with no difference according to the histotype. However, the rate of amplification increased to 36% in the G2/hormone receptor-negative cases as compared to 10.6% in the G2/receptor-positive cases (p

Original languageEnglish
Pages (from-to)1271-1275
Number of pages5
JournalOncology Reports
Volume19
Issue number5
Publication statusPublished - May 2008

Keywords

  • Breast
  • Cancer
  • Effectiveness
  • Fluorescence in situ hybridisation
  • HER2
  • Metastases

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Castellano, I., Sapino, A., Arisio, R., Viale, G., Bussolati, G., Bandelloni, R., Barresi, G., Bersiga, A., Bordi, C., Botti, G., Cosimi, F., D'Amore, E., Doglioni, C., Marchetti, A., Nappi, O., Romeo, F., Roncalli, M., Russo, R., Santinelli, A., ... Iurlaro, M. (2008). Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases. Oncology Reports, 19(5), 1271-1275.