Fluorescent molecularly imprinted nanogels for the detection of anticancer drugs in human plasma

Elena Pellizzoni, Martina Tommasini, Elena Marangon, Flavio Rizzolio, Gabriele Saito, Fabio Benedetti, Giuseppe Toffoli, Marina Resmini, Federico Berti

Research output: Contribution to journalArticlepeer-review

Abstract

Several fluorescent molecularly imprinted nanogels for the detection of the anticancer drug sunitinib were synthesized and characterized. A selection of functional monomers based on different aminoacids and coumarin allowed isolation of polymers with very good rebinding properties and sensitivities. The direct detection of sunitinib in human plasma was successfully demonstrated by fluorescence quenching of the coumarin-based nanogels. The plasma sample simply diluted in DMSO allowed the recovery of various amounts of sunitib, as determined by an averaged calibration curve. The LOD was 400 nM, with within-run variability

Original languageEnglish
Pages (from-to)913-919
Number of pages7
JournalBiosensors and Bioelectronics
Volume86
DOIs
Publication statusPublished - Dec 15 2016

Keywords

  • Anticancer drugs
  • Fluorimetry
  • Human plasma
  • Imprinted polymers
  • Therapeutic drug monitoring

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Biotechnology
  • Electrochemistry

Fingerprint Dive into the research topics of 'Fluorescent molecularly imprinted nanogels for the detection of anticancer drugs in human plasma'. Together they form a unique fingerprint.

Cite this