TY - JOUR
T1 - Fluorinated and charged hydrogenated alkanethiolates grafted on gold
T2 - Expanding the diversity of mixed-monolayer nanoparticles for biological applications
AU - Bidoggia, Silvia
AU - Milocco, Francesca
AU - Polizzi, Stefano
AU - Canton, Patrizia
AU - Saccani, Alessanda
AU - Sanavio, Barbara
AU - Krol, Silke
AU - Stellacci, Francesco
AU - Pengo, Paolo
AU - Pasquato, Lucia
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Low intrinsic toxicity, high solubility, and stability are important and necessary features of gold nanoparticles to be used in the biomedical field. In this context, charged nanoparticles proved to be very versatile, and among them charged mixed-monolayer gold nanoparticles, displaying monolayers with well-defined morphologies, represent a paradigm. By using mixtures of hydrogenated and fluorinated thiols, the formation of monolayer domains may be brought to an extreme because of the immiscibility of fluorinated and hydrogenated chains. Following this rationale, mixed monolayer gold nanoparticles featuring ammonium, sulfonate, or carboxylic groups on their surface were prepared by using amphiphilic hydrogenated thiols and 1H,1H,2H,2H-perfluoro-alkanethiols. The toxicity of these systems was assessed in HeLa cells and was found to be, in general, low even for the cationic nanoparticles which usually show a high cytotoxicity and is comparable to that of homoligand gold nanoparticles displaying amphiphilic-charge neutral-hydrogenated or fluorinated thiolates in their monolayer. These properties make the mixed ligand monolayer gold nanoparticles an interesting new candidate for medical application.
AB - Low intrinsic toxicity, high solubility, and stability are important and necessary features of gold nanoparticles to be used in the biomedical field. In this context, charged nanoparticles proved to be very versatile, and among them charged mixed-monolayer gold nanoparticles, displaying monolayers with well-defined morphologies, represent a paradigm. By using mixtures of hydrogenated and fluorinated thiols, the formation of monolayer domains may be brought to an extreme because of the immiscibility of fluorinated and hydrogenated chains. Following this rationale, mixed monolayer gold nanoparticles featuring ammonium, sulfonate, or carboxylic groups on their surface were prepared by using amphiphilic hydrogenated thiols and 1H,1H,2H,2H-perfluoro-alkanethiols. The toxicity of these systems was assessed in HeLa cells and was found to be, in general, low even for the cationic nanoparticles which usually show a high cytotoxicity and is comparable to that of homoligand gold nanoparticles displaying amphiphilic-charge neutral-hydrogenated or fluorinated thiolates in their monolayer. These properties make the mixed ligand monolayer gold nanoparticles an interesting new candidate for medical application.
UR - http://www.scopus.com/inward/record.url?scp=85021859088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021859088&partnerID=8YFLogxK
U2 - 10.1021/acs.bioconjchem.6b00585
DO - 10.1021/acs.bioconjchem.6b00585
M3 - Article
C2 - 28095690
AN - SCOPUS:85021859088
VL - 28
SP - 43
EP - 52
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
SN - 1043-1802
IS - 1
ER -