Fluorinated NSC as a Cdc25 inhibitor

Hwangseo Park, Brian I. Carr, Minghua Li, Seung Wook Ham

Research output: Contribution to journalArticlepeer-review

Abstract

We report on the fluorinated form of NSC 95397 as a Cdc25B inhibitor, which is predicted to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species.

Original languageEnglish
Pages (from-to)2351-2354
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number8
DOIs
Publication statusPublished - Apr 15 2007

Keywords

  • Antitumor
  • Cdc25 phosphatase
  • Inhibitor
  • Modeling
  • Quinones

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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