Fluorinated NSC as a Cdc25 inhibitor

Hwangseo Park, Brian I. Carr, Minghua Li, Seung Wook Ham

Research output: Contribution to journalArticle

Abstract

We report on the fluorinated form of NSC 95397 as a Cdc25B inhibitor, which is predicted to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species.

Original languageEnglish
Pages (from-to)2351-2354
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number8
DOIs
Publication statusPublished - Apr 15 2007

Fingerprint

2,3-bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone
Cysteine
Reactive Oxygen Species
Proteins

Keywords

  • Antitumor
  • Cdc25 phosphatase
  • Inhibitor
  • Modeling
  • Quinones

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Fluorinated NSC as a Cdc25 inhibitor. / Park, Hwangseo; Carr, Brian I.; Li, Minghua; Ham, Seung Wook.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 8, 15.04.2007, p. 2351-2354.

Research output: Contribution to journalArticle

Park, Hwangseo ; Carr, Brian I. ; Li, Minghua ; Ham, Seung Wook. / Fluorinated NSC as a Cdc25 inhibitor. In: Bioorganic and Medicinal Chemistry Letters. 2007 ; Vol. 17, No. 8. pp. 2351-2354.
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