Fluorinated PLGA Nanoparticles for Enhanced Drug Encapsulation and 19F NMR Detection

Giulia Neri, Giuliana Mion, Andrea Pizzi, Wanda Celentano, Linda Chaabane, Michele R. Chierotti, Roberto Gobetto, Min Li, Piergiorgio Messa, Floryan De Campo, Francesco Cellesi, Pierangelo Metrangolo, Francesca Baldelli Bombelli

Research output: Contribution to journalArticlepeer-review

Abstract

In the continuous search for multimodal systems with combined diagnostic and therapeutic functions, several efforts have been made to develop multifunctional drug delivery systems. In this work, through a covalent approach, a new class of fluorinated poly(lactic-co-glycolic acid) co-polymers (F-PLGA) were designed that contain an increasing number of magnetically equivalent fluorine atoms. In particular, two novel compounds, F3-PLGA and F9-PLGA, were synthesized and their chemical structure and thermal stability were analyzed by solution NMR, DSC, and TGA. The obtained F-PLGA compounds were proven to form in aqueous solution colloidal stable nanoparticles (NPs) displaying a strong 19F NMR signal. The fluorinated NPs also showed an enhanced ability to load hydrophobic drugs containing fluorine atoms compared to analogous pristine PLGA NPs. Preliminary in vitro studies showed high cell viability and the NP ability to intracellularly deliver and release a functioning drug.

Original languageEnglish
Pages (from-to)10057-10063
JournalChemistry - A European Journal
Volume26
Issue number44
DOIs
Publication statusPublished - 2020

Keywords

  • drug delivery
  • fluorine
  • nanomedicine
  • nanoparticles

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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