Fluorinated PLGA Nanoparticles for Enhanced Drug Encapsulation and 19F NMR Detection: Chemistry - A European Journal

G. Neri, G. Mion, A. Pizzi, W. Celentano, L. Chaabane, M.R. Chierotti, R. Gobetto, M. Li, P. Messa, F. De Campo, F. Cellesi, P. Metrangolo, F. Baldelli Bombelli

Research output: Contribution to journalArticlepeer-review


In the continuous search for multimodal systems with combined diagnostic and therapeutic functions, several efforts have been made to develop multifunctional drug delivery systems. In this work, through a covalent approach, a new class of fluorinated poly(lactic-co-glycolic acid) co-polymers (F-PLGA) were designed that contain an increasing number of magnetically equivalent fluorine atoms. In particular, two novel compounds, F3-PLGA and F9-PLGA, were synthesized and their chemical structure and thermal stability were analyzed by solution NMR, DSC, and TGA. The obtained F-PLGA compounds were proven to form in aqueous solution colloidal stable nanoparticles (NPs) displaying a strong 19F NMR signal. The fluorinated NPs also showed an enhanced ability to load hydrophobic drugs containing fluorine atoms compared to analogous pristine PLGA NPs. Preliminary in vitro studies showed high cell viability and the NP ability to intracellularly deliver and release a functioning drug. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Original languageEnglish
Pages (from-to)10057-10063
Number of pages7
JournalChem. Eur. J.
Issue number44
Publication statusPublished - 2020


  • drug delivery
  • fluorine
  • nanomedicine
  • nanoparticles
  • Chemical analysis
  • Chemical stability
  • Controlled drug delivery
  • Equivalence classes
  • Nanoparticles
  • Sols
  • Combined diagnostics
  • Drug delivery system
  • Drug encapsulation
  • Multimodal system
  • Nanoparticle (NPs)
  • PLGA nanoparticles
  • Poly lactic-co-glycolic acid
  • Therapeutic functions
  • Targeted drug delivery


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