Fluorinated PLGA Nanoparticles for Enhanced Drug Encapsulation and 19F NMR Detection: Chemistry - A European Journal

G. Neri; G. Mion; A. Pizzi; W. Celentano; L. Chaabane; M.R. Chierotti; R. Gobetto; M. Li; P. Messa; F. De Campo; F. Cellesi; P. Metrangolo; F. Baldelli Bombelli

doi:10.1002/chem.202002078

Fluorinated PLGA Nanoparticles for Enhanced Drug Encapsulation and 19F NMR Detection: Chemistry - A European Journal

G. Neri, G. Mion, A. Pizzi, W. Celentano, L. Chaabane, M.R. Chierotti, R. Gobetto, M. Li, P. Messa, F. De Campo, F. Cellesi, P. Metrangolo, F. Baldelli Bombelli

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

In the continuous search for multimodal systems with combined diagnostic and therapeutic functions, several efforts have been made to develop multifunctional drug delivery systems. In this work, through a covalent approach, a new class of fluorinated poly(lactic-co-glycolic acid) co-polymers (F-PLGA) were designed that contain an increasing number of magnetically equivalent fluorine atoms. In particular, two novel compounds, F3-PLGA and F9-PLGA, were synthesized and their chemical structure and thermal stability were analyzed by solution NMR, DSC, and TGA. The obtained F-PLGA compounds were proven to form in aqueous solution colloidal stable nanoparticles (NPs) displaying a strong 19F NMR signal. The fluorinated NPs also showed an enhanced ability to load hydrophobic drugs containing fluorine atoms compared to analogous pristine PLGA NPs. Preliminary in vitro studies showed high cell viability and the NP ability to intracellularly deliver and release a functioning drug. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Original language	English
Pages (from-to)	10057-10063
Number of pages	7
Journal	Chem. Eur. J.
Volume	26
Issue number	44
DOIs	https://doi.org/10.1002/chem.202002078
Publication status	Published - 2020

Keywords

drug delivery
fluorine
nanomedicine
nanoparticles
Chemical analysis
Chemical stability
Controlled drug delivery
Equivalence classes
Nanoparticles
Sols
Combined diagnostics
Drug delivery system
Drug encapsulation
Multimodal system
Nanoparticle (NPs)
PLGA nanoparticles
Poly lactic-co-glycolic acid
Therapeutic functions
Targeted drug delivery

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Neri, G., Mion, G., Pizzi, A., Celentano, W., Chaabane, L., Chierotti, M. R., Gobetto, R., Li, M., Messa, P., De Campo, F., Cellesi, F., Metrangolo, P., & Baldelli Bombelli, F. (2020). Fluorinated PLGA Nanoparticles for Enhanced Drug Encapsulation and 19F NMR Detection: Chemistry - A European Journal. Chem. Eur. J., 26(44), 10057-10063. https://doi.org/10.1002/chem.202002078

Fluorinated PLGA Nanoparticles for Enhanced Drug Encapsulation and 19F NMR Detection : Chemistry - A European Journal. / Neri, G.; Mion, G.; Pizzi, A.; Celentano, W.; Chaabane, L.; Chierotti, M.R.; Gobetto, R.; Li, M.; Messa, P.; De Campo, F.; Cellesi, F.; Metrangolo, P.; Baldelli Bombelli, F.

In: Chem. Eur. J., Vol. 26, No. 44, 2020, p. 10057-10063.

Research output: Contribution to journal › Article › peer-review

Neri, G, Mion, G, Pizzi, A, Celentano, W, Chaabane, L, Chierotti, MR, Gobetto, R, Li, M, Messa, P, De Campo, F, Cellesi, F, Metrangolo, P & Baldelli Bombelli, F 2020, 'Fluorinated PLGA Nanoparticles for Enhanced Drug Encapsulation and 19F NMR Detection: Chemistry - A European Journal', Chem. Eur. J., vol. 26, no. 44, pp. 10057-10063. https://doi.org/10.1002/chem.202002078

@article{46782b64f26c41299523daa0096cc2ad,

title = "Fluorinated PLGA Nanoparticles for Enhanced Drug Encapsulation and 19F NMR Detection: Chemistry - A European Journal",

abstract = "In the continuous search for multimodal systems with combined diagnostic and therapeutic functions, several efforts have been made to develop multifunctional drug delivery systems. In this work, through a covalent approach, a new class of fluorinated poly(lactic-co-glycolic acid) co-polymers (F-PLGA) were designed that contain an increasing number of magnetically equivalent fluorine atoms. In particular, two novel compounds, F3-PLGA and F9-PLGA, were synthesized and their chemical structure and thermal stability were analyzed by solution NMR, DSC, and TGA. The obtained F-PLGA compounds were proven to form in aqueous solution colloidal stable nanoparticles (NPs) displaying a strong 19F NMR signal. The fluorinated NPs also showed an enhanced ability to load hydrophobic drugs containing fluorine atoms compared to analogous pristine PLGA NPs. Preliminary in vitro studies showed high cell viability and the NP ability to intracellularly deliver and release a functioning drug. {\textcopyright} 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

keywords = "drug delivery, fluorine, nanomedicine, nanoparticles, Chemical analysis, Chemical stability, Controlled drug delivery, Equivalence classes, Nanoparticles, Sols, Combined diagnostics, Drug delivery system, Drug encapsulation, Multimodal system, Nanoparticle (NPs), PLGA nanoparticles, Poly lactic-co-glycolic acid, Therapeutic functions, Targeted drug delivery",

author = "G. Neri and G. Mion and A. Pizzi and W. Celentano and L. Chaabane and M.R. Chierotti and R. Gobetto and M. Li and P. Messa and {De Campo}, F. and F. Cellesi and P. Metrangolo and {Baldelli Bombelli}, F.",

note = "Cited By :2 Export Date: 11 March 2021 CODEN: CEUJE Correspondence Address: Baldelli Bombelli, F.; Laboratory of Supramolecular and Bio-Nanomaterials (SupraBioNanoLab), V. Luigi Mancinelli, Italy; email: francesca.baldelli@polimi.it Funding details: 1175999, 2017MYBTXC Funding text 1: We thank Solvay Specialty Polymers for supporting and funding this research project. P.M. and F.B.B. are also thankful to NEWMED project ID: 1175999 (funded by Regione Lombardia?POR FESR 2014 2020) and PRIN2017-NiFTy (2017MYBTXC) for additional support.",

year = "2020",

doi = "10.1002/chem.202002078",

language = "English",

volume = "26",

pages = "10057--10063",

journal = "Chem. Eur. J.",

issn = "0947-6539",

publisher = "Wiley-VCH Verlag",

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TY - JOUR

T1 - Fluorinated PLGA Nanoparticles for Enhanced Drug Encapsulation and 19F NMR Detection

T2 - Chemistry - A European Journal

AU - Neri, G.

AU - Mion, G.

AU - Pizzi, A.

AU - Celentano, W.

AU - Chaabane, L.

AU - Chierotti, M.R.

AU - Gobetto, R.

AU - Li, M.

AU - Messa, P.

AU - De Campo, F.

AU - Cellesi, F.

AU - Metrangolo, P.

AU - Baldelli Bombelli, F.

N1 - Cited By :2 Export Date: 11 March 2021 CODEN: CEUJE Correspondence Address: Baldelli Bombelli, F.; Laboratory of Supramolecular and Bio-Nanomaterials (SupraBioNanoLab), V. Luigi Mancinelli, Italy; email: francesca.baldelli@polimi.it Funding details: 1175999, 2017MYBTXC Funding text 1: We thank Solvay Specialty Polymers for supporting and funding this research project. P.M. and F.B.B. are also thankful to NEWMED project ID: 1175999 (funded by Regione Lombardia?POR FESR 2014 2020) and PRIN2017-NiFTy (2017MYBTXC) for additional support.

PY - 2020

Y1 - 2020

N2 - In the continuous search for multimodal systems with combined diagnostic and therapeutic functions, several efforts have been made to develop multifunctional drug delivery systems. In this work, through a covalent approach, a new class of fluorinated poly(lactic-co-glycolic acid) co-polymers (F-PLGA) were designed that contain an increasing number of magnetically equivalent fluorine atoms. In particular, two novel compounds, F3-PLGA and F9-PLGA, were synthesized and their chemical structure and thermal stability were analyzed by solution NMR, DSC, and TGA. The obtained F-PLGA compounds were proven to form in aqueous solution colloidal stable nanoparticles (NPs) displaying a strong 19F NMR signal. The fluorinated NPs also showed an enhanced ability to load hydrophobic drugs containing fluorine atoms compared to analogous pristine PLGA NPs. Preliminary in vitro studies showed high cell viability and the NP ability to intracellularly deliver and release a functioning drug. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

AB - In the continuous search for multimodal systems with combined diagnostic and therapeutic functions, several efforts have been made to develop multifunctional drug delivery systems. In this work, through a covalent approach, a new class of fluorinated poly(lactic-co-glycolic acid) co-polymers (F-PLGA) were designed that contain an increasing number of magnetically equivalent fluorine atoms. In particular, two novel compounds, F3-PLGA and F9-PLGA, were synthesized and their chemical structure and thermal stability were analyzed by solution NMR, DSC, and TGA. The obtained F-PLGA compounds were proven to form in aqueous solution colloidal stable nanoparticles (NPs) displaying a strong 19F NMR signal. The fluorinated NPs also showed an enhanced ability to load hydrophobic drugs containing fluorine atoms compared to analogous pristine PLGA NPs. Preliminary in vitro studies showed high cell viability and the NP ability to intracellularly deliver and release a functioning drug. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

KW - drug delivery

KW - fluorine

KW - nanomedicine

KW - nanoparticles

KW - Chemical analysis

KW - Chemical stability

KW - Controlled drug delivery

KW - Equivalence classes

KW - Nanoparticles

KW - Sols

KW - Combined diagnostics

KW - Drug delivery system

KW - Drug encapsulation

KW - Multimodal system

KW - Nanoparticle (NPs)

KW - PLGA nanoparticles

KW - Poly lactic-co-glycolic acid

KW - Therapeutic functions

KW - Targeted drug delivery

U2 - 10.1002/chem.202002078

DO - 10.1002/chem.202002078

M3 - Article

VL - 26

SP - 10057

EP - 10063

JO - Chem. Eur. J.

JF - Chem. Eur. J.

SN - 0947-6539

IS - 44

ER -